{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Z"],"funding":["DFG-Deutsche Forschungsgemeinschaft","Germany's Excellence Strategy, EXC 2155 RESIST","DFG-funded research group FOR2799"],"pagination":["e70061"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12449965"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55(9)"],"pubmed_abstract":["γδ T cells are unconventional T cells that group into different subsets based on the usage of variable γδ T cell receptor (TCR) gene segments, body location, and functionality. γδ T cells that secrete the proinflammatory cytokine interleukin 17 (IL-17) predominantly express a Vγ4<sup>+</sup> or Vγ6<sup>+</sup> γδ TCR. The biology and the importance of the γδ TCR of IL-17-producing γδ T cells are not well understood. Here, we investigated the IL-17 production capability of γδ T cells in mice deficient for Vγ4<sup>+</sup> and Vγ6<sup>+</sup> γδ TCRs using flow cytometry, TCR-seq, and single-cell transcriptomics. Our data show that Vγ1 T cells only partially compensate for the loss of IL-17<sup>+</sup> Vγ4 and Vγ6 T cell subsets in lymphoid and nonlymphoid tissues. They develop pre- and postn"],"journal":["European journal of immunology"],"pubmed_title":["Partial Compensation of IL-17 Production by Vγ1 T Cells in the Absence of Vγ4 and Vγ6 T Cells."],"pmcid":["PMC12449965"],"funding_grant_id":["390874280","RA3077/1-2"],"pubmed_authors":["Sandrock I","Coffelt SB","Janssen A","Prinz I","Lupo F","Yang T","Wang Z","Ravens S","Behrens LM"],"additional_accession":[]},"is_claimable":false,"name":"Partial Compensation of IL-17 Production by Vγ1 T Cells in the Absence of Vγ4 and Vγ6 T Cells.","description":"γδ T cells are unconventional T cells that group into different subsets based on the usage of variable γδ T cell receptor (TCR) gene segments, body location, and functionality. γδ T cells that secrete the proinflammatory cytokine interleukin 17 (IL-17) predominantly express a Vγ4<sup>+</sup> or Vγ6<sup>+</sup> γδ TCR. The biology and the importance of the γδ TCR of IL-17-producing γδ T cells are not well understood. Here, we investigated the IL-17 production capability of γδ T cells in mice deficient for Vγ4<sup>+</sup> and Vγ6<sup>+</sup> γδ TCRs using flow cytometry, TCR-seq, and single-cell transcriptomics. Our data show that Vγ1 T cells only partially compensate for the loss of IL-17<sup>+</sup> Vγ4 and Vγ6 T cell subsets in lymphoid and nonlymphoid tissues. They develop pre- and postn","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T15:16:15.352Z","creation":"2026-04-29T03:09:05.341Z"},"accession":"S-EPMC12449965","cross_references":{"pubmed":["40974348"],"doi":["10.1002/eji.70061"]}}