{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(13)"],"submitter":["Li W"],"pubmed_abstract":["<h4>Background</h4>Epidemiological data suggest that the risk of ischemic stroke increases after varicella-zoster virus (VZV) reactivation. The frequency of VZV reactivation in acute ischemic stroke (AIS) is unknown. The risk of recurrent stroke and the antiviral treatment effect, particularly in patients with HIV infection, have yet to be defined. Here, we investigate the proportion of VZV reactivation in the cerebrospinal fluid (CSF) of patients who presented with AIS or transient ischemic attack and underwent VZV testing, along with relevant follow-up information.<h4>Methods</h4>We retrospectively reviewed medical records of patients who presented with AIS or transient ischemic attack and underwent VZV polymerase chain reaction and anti-VZV IgG testing in CSF during their workup from Ja"],"journal":["Journal of the American Heart Association"],"pagination":["e039489"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12449971"],"repository":["biostudies-literature"],"pubmed_title":["Detection of Varicella Zoster Virus Reactivation in Cerebrospinal Fluid in Ischemic Stroke or Transient Ischemic Attack."],"pmcid":["PMC12449971"],"pubmed_authors":["Li W","Husari KS","Johnson M","Salahuddin H","Magadan A","Rupareliya C","Moore W","Nijhawan AE","Grose C","Shang T","Sguigna P","Subramanian S"],"additional_accession":[]},"is_claimable":false,"name":"Detection of Varicella Zoster Virus Reactivation in Cerebrospinal Fluid in Ischemic Stroke or Transient Ischemic Attack.","description":"<h4>Background</h4>Epidemiological data suggest that the risk of ischemic stroke increases after varicella-zoster virus (VZV) reactivation. The frequency of VZV reactivation in acute ischemic stroke (AIS) is unknown. The risk of recurrent stroke and the antiviral treatment effect, particularly in patients with HIV infection, have yet to be defined. Here, we investigate the proportion of VZV reactivation in the cerebrospinal fluid (CSF) of patients who presented with AIS or transient ischemic attack and underwent VZV testing, along with relevant follow-up information.<h4>Methods</h4>We retrospectively reviewed medical records of patients who presented with AIS or transient ischemic attack and underwent VZV polymerase chain reaction and anti-VZV IgG testing in CSF during their workup from Ja","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-06-03T14:28:44.037Z","creation":"2026-04-28T03:11:33.303Z"},"accession":"S-EPMC12449971","cross_references":{"pubmed":["40530491"],"doi":["10.1161/JAHA.124.039489"]}}