{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fickling LJ"],"funding":["University of Wisconsin-Madison (UW)","HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIDDK NIH HHS","Wisconsin Alumni Research Foundation (WARF)","NCRR NIH HHS","HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","NSF | EDU | Division of Graduate Education (DGE)","NINDS NIH HHS","University of Pennsylvania (Penn)","HHS | NIH | National Center for Research Resources (NCRR)","NSF | MPS | Division of Chemistry (CHE)","NIH HHS"],"pagination":["642-666"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12450063"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["134(2)"],"pubmed_abstract":["Studies of hormone influences on neural circuits and behavior have primarily focused on the manipulation of individual hormones. Here, we examine the influence of behavioral (feeding) state-specific hormonal environments on the gastric mill (chewing) circuit configured by the neuropeptide Gly<sup>1</sup>-SIFamide (G-SIFamide) in the isolated <i>Cancer borealis</i> stomatogastric ganglion (STG). The G-SIFamide-activated gastric mill rhythm, which is similar to that driven by the G-SIFamidergic projection neuron modulatory commissural neuron 5 (MCN5), is distinguished from other gastric mill rhythms by the presence of rhythmic, prolonged inferior cardiac (IC) neuron bursts and associated interruptions of the pyloric rhythm. Applying 1 µM G-SIFamide in saline only occasionally activated the g"],"journal":["Journal of neurophysiology"],"pubmed_title":["Feeding state-specific hormonal tuning of neural circuit modulation."],"pmcid":["PMC12450063"],"funding_grant_id":["NCRR-S10RR029531","CHE-2108223","NCRR-S10OD025084","S10 OD028473","S10 OD025084","NCRR-S10OD028473","R01-DK071801","DGE-2137424","R01 NS029436","R01-NS029436","R01 DK071801","S10 RR029531"],"pubmed_authors":["Fickling LJ","Ibarra AE","Nusbaum MP","Wu W","Li L","Cook AP"],"additional_accession":[]},"is_claimable":false,"name":"Feeding state-specific hormonal tuning of neural circuit modulation.","description":"Studies of hormone influences on neural circuits and behavior have primarily focused on the manipulation of individual hormones. Here, we examine the influence of behavioral (feeding) state-specific hormonal environments on the gastric mill (chewing) circuit configured by the neuropeptide Gly<sup>1</sup>-SIFamide (G-SIFamide) in the isolated <i>Cancer borealis</i> stomatogastric ganglion (STG). The G-SIFamide-activated gastric mill rhythm, which is similar to that driven by the G-SIFamidergic projection neuron modulatory commissural neuron 5 (MCN5), is distinguished from other gastric mill rhythms by the presence of rhythmic, prolonged inferior cardiac (IC) neuron bursts and associated interruptions of the pyloric rhythm. Applying 1 µM G-SIFamide in saline only occasionally activated the g","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-28T03:21:57.426Z","creation":"2026-04-28T03:11:37.338Z"},"accession":"S-EPMC12450063","cross_references":{"pubmed":["40658597"],"doi":["10.1152/jn.00164.2025"]}}