biostudies-literatureFord HNational Institute of Food and Agriculture128https://www.ebi.ac.uk/biostudies/studies/S-EPMC12450340biostudies-literatureUnknown16(1)<h4>Background</h4>Adipose tissue plays a central role in regulating whole-body metabolic health, facilitated by the variety of cell types and their wide-ranging functions. In addition, depot-specific differences in adipose tissue have been shown to play important roles in different disease states including obesity, diabetes, and metabolic dysfunction in human and animal models. For early postpartum dairy cattle, metabolic dysfunction, triggered by a negative energy balance, is often manifested as subclinical ketosis (SCK). However, the role that subcutaneous (SAT) and visceral (VAT) adipose tissue depots, and their diverse cellular compositions, play in the response to subclinical ketosis conditions is unclear.<h4>Results</h4>Flank SAT and omental VAT were collected via laparotomy from fiJournal of animal science and biotechnologyDepot-dependent effects of subclinical ketosis on visceral and subcutaneous adipose tissue transcriptional cellular diversity in dairy cows.PMC124503402022-67015-36319Ford HStrieder-Barboza CfalseDepot-dependent effects of subclinical ketosis on visceral and subcutaneous adipose tissue transcriptional cellular diversity in dairy cows.<h4>Background</h4>Adipose tissue plays a central role in regulating whole-body metabolic health, facilitated by the variety of cell types and their wide-ranging functions. In addition, depot-specific differences in adipose tissue have been shown to play important roles in different disease states including obesity, diabetes, and metabolic dysfunction in human and animal models. For early postpartum dairy cattle, metabolic dysfunction, triggered by a negative energy balance, is often manifested as subclinical ketosis (SCK). However, the role that subcutaneous (SAT) and visceral (VAT) adipose tissue depots, and their diverse cellular compositions, play in the response to subclinical ketosis conditions is unclear.<h4>Results</h4>Flank SAT and omental VAT were collected via laparotomy from fi2025-01-01T00:00:00Z2025 Sep2026-04-29T03:19:23.019Z2026-04-29T03:12:47.916ZS-EPMC124503404097576710.1186/s40104-025-01265-y