{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Yang F"],"pubmed_abstract":["<h4>Introduction</h4><i>Tetrastigma hemsleyanum</i> Diels et Gilg (Vitaceae) is a medicinally valuable plant typically with a whitish root cross-section. Resource surveys discovered some roots of <i>T. hemsleyanum</i> with a yellow-brown root cross-section and stronger antioxidant properties. However, the molecular mechanisms underlying these phenotypic differences remain poorly understood.<h4>Methods</h4>We employed integrated metabolomic and transcriptomic analyses to compare the two root types. Key candidate genes were cloned and functionally characterized to uncover the regulatory mechanisms involved.<h4>Results</h4>Metabolomic analysis identified significant changes in 217 metabolites between the two types, among which 57 flavonoids, such as Hesperetin-7-O-glucoside, were significantl"],"journal":["Frontiers in plant science"],"pagination":["1642835"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12450873"],"repository":["biostudies-literature"],"pubmed_title":["Multi-omics analysis reveals ThMYB6 regulation of flavonoid biosynthesis in differently colored tuberous roots of &lt;i&gt;Tetrastigma hemsleyanum&lt;/i&gt;."],"pmcid":["PMC12450873"],"pubmed_authors":["Shen Q","Li S","Gu Y","Liu S","Wang H","Feng B","Bai Y","Wang Z","Yang F","Xing Q"],"additional_accession":[]},"is_claimable":false,"name":"Multi-omics analysis reveals ThMYB6 regulation of flavonoid biosynthesis in differently colored tuberous roots of &lt;i&gt;Tetrastigma hemsleyanum&lt;/i&gt;.","description":"<h4>Introduction</h4><i>Tetrastigma hemsleyanum</i> Diels et Gilg (Vitaceae) is a medicinally valuable plant typically with a whitish root cross-section. Resource surveys discovered some roots of <i>T. hemsleyanum</i> with a yellow-brown root cross-section and stronger antioxidant properties. However, the molecular mechanisms underlying these phenotypic differences remain poorly understood.<h4>Methods</h4>We employed integrated metabolomic and transcriptomic analyses to compare the two root types. Key candidate genes were cloned and functionally characterized to uncover the regulatory mechanisms involved.<h4>Results</h4>Metabolomic analysis identified significant changes in 217 metabolites between the two types, among which 57 flavonoids, such as Hesperetin-7-O-glucoside, were significantl","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-04-30T03:19:59.562Z","creation":"2026-04-30T03:12:03.506Z"},"accession":"S-EPMC12450873","cross_references":{"pubmed":["40989730"],"doi":["10.3389/fpls.2025.1642835"]}}