biostudies-literatureUnknown12Wang L<h4>Objectives</h4>Atrial fibrillation/flutter (AF/AFL) is increasingly correlated with metabolic risk factors. This study analyzed mortality, disability-adjusted life years (DALYs), annual percentage changes (APCs), and estimated annual percentage changes (EAPCs), stratified by age, sex, Socio-demographic Index (SDI), and region, to evaluate the global burden of AF/AFL linked to metabolic risk factors.<h4>Methods</h4>Data on prevalence, incidence, mortality, DALYs, and age-standardized rates (ASRs) for AF/AFL associated with metabolic risk factors were extracted from the Global Burden of Disease (GBD) 2021 study. EAPCs were used to assess temporal trends in ASRs.<h4>Results</h4>In 2021, metabolic risk factors were correlated with approximately 117,012 deaths and 2,881,800 DALYs globally dFrontiers in cardiovascular medicine1578908https://www.ebi.ac.uk/biostudies/studies/S-EPMC12450952biostudies-literatureGlobal, regional, and national burden of atrial fibrillation and flutter associated with metabolic risk factors, 1990-2021.PMC12450952Qin XLiu PWang HGong HGao CWang LJin LfalseGlobal, regional, and national burden of atrial fibrillation and flutter associated with metabolic risk factors, 1990-2021.<h4>Objectives</h4>Atrial fibrillation/flutter (AF/AFL) is increasingly correlated with metabolic risk factors. This study analyzed mortality, disability-adjusted life years (DALYs), annual percentage changes (APCs), and estimated annual percentage changes (EAPCs), stratified by age, sex, Socio-demographic Index (SDI), and region, to evaluate the global burden of AF/AFL linked to metabolic risk factors.<h4>Methods</h4>Data on prevalence, incidence, mortality, DALYs, and age-standardized rates (ASRs) for AF/AFL associated with metabolic risk factors were extracted from the Global Burden of Disease (GBD) 2021 study. EAPCs were used to assess temporal trends in ASRs.<h4>Results</h4>In 2021, metabolic risk factors were correlated with approximately 117,012 deaths and 2,881,800 DALYs globally d2025-01-01T00:00:00Z20252026-06-03T18:48:34.808Z2026-04-30T03:11:18.105ZS-EPMC124509524098911410.3389/fcvm.2025.1578908