biostudies-literatureTjaden AHNational Institute of Diabetes and Digestive and Kidney DiseasesNIDDK NIH HHSNIA NIH HHSNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1685-1694https://www.ebi.ac.uk/biostudies/studies/S-EPMC12451849biostudies-literatureUnknown48(10)<h4>Objective</h4>Success of longitudinal studies depends on retention of participants. We examined characteristics as predictors of retention among participants with prediabetes and type 2 diabetes (T2D) in the Diabetes Prevention Program (DPP) and the follow-up DPP Outcomes Study.<h4>Research design and methods</h4>A total of 3,234 adults at high risk of T2D joined the DPP (1996-1999, mean age 51 ± 10 years). They were randomized to lifestyle, metformin, or placebo intervention, and then followed through 2020. Logistic regression models estimated the association between baseline sociodemographic, clinical and psychosocial characteristics (life events, family functioning, social support), and short-term retention (∼3 years). Cox proportional hazards models, censoring at death, estimated tDiabetes careSociodemographic, Clinical, and Psychosocial Predictors of Short- and Long-term Study Retention in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS).PMC12451849U01 DK048349, U01 DK048381, U01 DK048468U01 DK048489, U01 DK048339, U01 DK048377,U01 DK048407U01 DK048434, U01 DK048485, U01 DK048375U01 DK048349U01 DK048404U01 DK048406U01 DK048443U01 DK048400U01 DK048514, U01 DK048437, U01 DK048413U01 DK048489U01 DK048468U01 DK048485U01 DK048387U01 DK048380U01 DK048381U01 DK048411, U01 DK048406, U01 DK048380U01 DK048437U01 DK048514U01 DK048339U19 AG078558U01 DK048377U01 DK048411U01 DK048434U01 DK048412U01 DK048413U01 DK048397U01 DK048375U01 DK048387, U01 DK048407, U01 DK048443U01 DK048397, U01 DK048412, U01 DK048404Caro JFLaferrere BCarmichael OTestaverde LHorse EKellum TSmith CFBoggs GJohnson MKBrancati FLPercy CAEnote ASmith CMKavena KLeon LSewenemewa JRoston SNgo KRochon JRyder LBudoff MHorak KBray GAMagee MTemprosa MFrazier MAdelman DTDavid KTorio-Hurley JFineberg ESVenditti EWalker TBowers AMau MKFisher ELiberoni RTjaden AHLevy EAldrich FABurkott HLBamdad JWeinzierl VMontgomery BKMiller MMcLymont VGroessl EReimers JLagarda MMarrero DGMagpuri PIsonaga MKSemler LSantiago AJenkins TNyenwe EALovejoy JCSaab PHaffner SMUwaifo GAndre VLNatewa CMcNabb WChai LMucik PQuinn MTBaldo MNelson JAFondino AWiggins RZimmerman ETemple KAHampton EFAtler LFGiannella ALyman MDiabetes Prevention Program Research GroupLambeth HApplegate WBBurge MRFarago MBarrett-Connor ELee JEMoran RRPolonsky KSO'Kelly Phillips EFowler SPiromalli CRuiz RSeely EWKramer MKDavis MMikami KBallonoff LBRubin RRMohideen PBarkalow MSteinke SCGoldstein AHyde PHaffner LSherman ARMayer-Davis EPompi DKatzir NGregg ESosa ALawton KEBezabeh TConzues CMcDaniel KChen LWells-Thayer DCallaghan JJanesch SSShuldiner ARPena MBSpencer CTonemah DSanguily JMartinez HMagee MFFreel JLoman KMills MSaad MFMartinez ANashboo YLachin JMSherif HHernandez-McGinnis DABenchoff CMyers DOldmixon CFLipkin EWDonahue RPReusing JMa YJohnson SBronsord MSullivan ECzech KGuillory FGNavy CFultz MAbbas CPrince MJJohnson DLukin JSchroeder EBPerry JAPrineas RGuido MHarden MKoenning GRicks HMiddendorf JPoirier CSOlefsky JMReinhart RStevens CReidy MMendez JLeander FAnderson EGrassa EOdom SKCanady JLWatson PGCassanova-Romero PHarris LAnderson HGoldman VLarsen DD'Anna KCarter CEFlorez JCTomuta NSantiago JVPoulos ASoliman EZMugford MDuffy HCastillo-Florez SKahn SELarkin MHurt ETsai ECSangster SRowe PMosley HSalazar MShah VChatellier AFargnoli BDanis RRubtchinsky SKilleen ANair AKKnopp RHKeasler LHivert MFKobus KMShields TCooeyate NYazzie MCook MClaravall LNRipley VGlass JArakaki RFPenn SCGohdes DGlass MTurgeon HCook SBegay SSeagle HJones TLBeltran MMau MThomas AImseis RPal CJinagouda SGaniats TTadros SDohm KCalles JCantrell CMLeos DThomas LShaw RHarting JRubinchik SLongchamp NRoy RJStewart KJJeffirs MLTrandafirescu GKloiber SCalonge BNDotson YFVicknair PCRoach PJCurtis JPutenney PMalloy MABryant MHill JOEhrmann DAMudaliar SFlorez HJCox LBarr SMendoza JBeddow RBissett LBaumhauer HWatson SYamamoto REGroessl EJTodd JNWatson KZonszein JMcAtee GSilverman AGreene AMathioudakis NHubbard LGreenway FJackson MABoxer RSSarkin AJMorgan-Taggart ISmart MGrover-Fairchild NWalker EAAllison DBAckermann RTBraffett BHAdams KSBroussard BAGuare JCDotson BEdgerton CGao YGabrielson DBird ECPollin TIMullen MYoussef GDwyer GMVanderMolen SDragg ARooney ESThangthaeng NDas SAlexander TSchade DSMcCabe CBrown ALGarfield SHoskin MAStrylewicz GBillings LKRojas-Cuevas MMunshi MMelancon LEFoo STFujimoto WLawrence DGrant WSchwartz ABarrett NNilan TMelish JSSt Amant JAStamm EPerry RUEberhardt BSmith FEdelstein SLPerry ASmith JPan JJay PPoirier SAdorno ESmith MBassiouni SWildman WPerreault LKula LMBenson MBPan QWhite NHKhare-Ranade PWing RRPatel ASoberman JEWilliams KVHartmuller MOtto ATaylor TCheatham WWChristophi CGoldstein BJTaylor LChampagne CMGoldberg RBMetzger BEJortberg BTRoumain JWilliams-Cleaves BBethepu JAronoff NJBotrous MDuncan RSemenske ARPalermo LBryer-Ash MGanda OPKatz PAbbott KKatz REwen APepe CLorenzo CGurry LGilligan RHall SDelve LHorton ESDailing CBrown JODolgoff JVeciana BHenry RRHu JCallaphan KMShapiro SNicosia MKnowler WCJohannes CWilliams RAltshuler DSenter WWylie-Rosett JGuimond SKitabchi AEGoulding AJablonski KBradley VHoward-Century CJParkes KCola SPettigrew JDowden JMDodge CSanford DARegensteiner JGJackson SDLevatan CKirby LPolonsky WBrown MBLatimer RWGhahate JMSchweizer DDuncan CHorne JMatulik MJOrchard TManus CBoraz MKelly-Dinham KGama VCulbert IWGuidi AMolitch MECarrion-Petersen MLOrlosky RTulley RTLockett Mde Groot MLou PCorkery EKirkman MSColleran KClifford LOktaei HHarrier SSchinleber PADacawyma TBehrends CLara OLarreal CSapozhnikova ARyan DHRubinstein DInouye JAbebe SKelly SMScheindlin JCulyba RFriedler ACohn HSaudek CDBrenneman TPinner KLRassam AHoyer SREvans GHurtenbach CGottlieb AEvans CLamkin MLarsen MDJohnson CKHPak JTrence DLi YViscovich KAColegrove CAlbers JNathan DMJones JFitzgibbon MVanDorsten BFradkin JElsas DJones SWarram JJones TMercader JMLedbury SAnderson DRJacobsen AMGooding RDelahanty LSwift MCaballero EMarr MRowland NDMaruthur NFranklin TMurphy MEKolinjivadi PJensen GPorter BDRaymond ESrinivasan SBermudez NEBain RTobian JJackson MHoffman HLindsay MMurillo AWheeler MLSoliman DDomalpally AKalyani RDeSandre CSimonson DSwift KWalker-Murray FZhang ZCappelli SKrakoff JLi JHButera NMMontez MGHattaway KRockette-Wagner BTruong JWilson TSamuels AZachwieja JJEdelman SVKocal MClark BFurlong KHamman RFClark DNoel AFattaleh BZhang PWallia AVejvoda KRatner RESmith LLHemphill CGiles MMButler NJeffries SChong HHerbert AAKaskalla RSAgharanya NKerr MJiggetts DSimmons MSolomon CGArceneaux JBurke JPKurland JCagliero EManjoo QPemberton NHanson RLDagogo-Jack SCharleston JBFranks PWShamoon HIbebuogu UEngel SLichtermann LCKessler DEndres RWhittington TLee CPowell DMarcovina SPitts TPrice DWKriska AAndon NRowse DHagamen SEastman RPolczynski EWernimont CArky RAMcPherson DHazuda HPAllen AO'Leary DSmith KGMichaels SWilson CReamer SGrimes KLActon KJLenz DSmith KAGibbs PRautaharju PHilbrich RLambert LSpandorfer JBenz WHadden AUtsey EGolden SHRainville RBarber RSansoucy JBrown ERautaharju FNash PVDabelea DPassaro MRoman JBondi KHensley SBudget MGarg RBouffard ALowe ARutledge LMKMcCowan SVan Wye GEHClark JMPark JIgnaut JMLuchsinger JAXapthalamous KHerman WHBoyle PJMorris LHStimpson CChavez MManly JPi-Sunyer FXStephens SDoughty MSBrandle MO'Neal KTseng BIsaac JVargo PSpellman JGonzales YMiddelbeek RJWWilliamson DQuitingon MWilliamson PCrandall JPBaker-Ladao NKBlodi BFrieson SLBavido-Arrage CIngraham LEAkbar KMcKitrick CStich TKing CViolino EKennedy BMGadde KMBucca BGarimella PAraneta MRFoulkes MMorgan TAroda VWaters DBennett PHCampbell CJoseph HDias LMather KJfalseSociodemographic, Clinical, and Psychosocial Predictors of Short- and Long-term Study Retention in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS).<h4>Objective</h4>Success of longitudinal studies depends on retention of participants. We examined characteristics as predictors of retention among participants with prediabetes and type 2 diabetes (T2D) in the Diabetes Prevention Program (DPP) and the follow-up DPP Outcomes Study.<h4>Research design and methods</h4>A total of 3,234 adults at high risk of T2D joined the DPP (1996-1999, mean age 51 ± 10 years). They were randomized to lifestyle, metformin, or placebo intervention, and then followed through 2020. Logistic regression models estimated the association between baseline sociodemographic, clinical and psychosocial characteristics (life events, family functioning, social support), and short-term retention (∼3 years). Cox proportional hazards models, censoring at death, estimated t2025-01-01T00:00:00Z2025 Oct2026-06-03T19:31:28.116Z2026-04-30T03:12:04.348ZS-EPMC124518494054125710.2337/dc25-0520