{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Medina-Martinez I"],"funding":["B-CTS-100-UGR20, Consejería de Economía, Innovación y Ciencia de la Junta de Andalucía I+D+i Programa operativo FEDER Andalucía 2014-2020"],"pagination":["151"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12452298"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["<b>Introduction</b>: Gut dysbiosis has been associated with the development of autoimmune diseases, including systemic lupus erythematosus (SLE). Although previous studies suggest microbial alterations in SLE, evidence at the species level and its clinical relevance remain limited. This study aimed to characterise the gut microbiota at species level in SLE patients and evaluate its association with clinical features. <b>Materials and methods</b>: A total of 57 SLE patients and 57 matched controls were included. Faecal samples were collected using the OMNIgene-GUT kit, and microbial DNA was extracted with the Maxwell RSC PureFood GMO kit. Metagenomic sequencing was performed using the Illumina MiSeq platform, and the data was analysed with QIIME2. Microbial diversity and relative abundance "],"journal":["Medical sciences (Basel, Switzerland)"],"pubmed_title":["Association of Gut Dysbiosis with Disease Phenotype and Treatment in Systemic Lupus Erythematosus."],"pmcid":["PMC12452298"],"funding_grant_id":["20.000 €"],"pubmed_authors":["Garcia-Garcia J","Zamora-Pasadas M","Rueda-Medina B","Gil-Gutierrez R","Correa-Rodriguez M","Garcia-Garcia F","de la Hera-Fernandez FJ","Ortego-Centeno N","Callejas-Rubio JL","Galvez-Peralta J","Rodriguez-Nogales A","Navarrete-Navarrete N","Medina-Martinez I"],"additional_accession":[]},"is_claimable":false,"name":"Association of Gut Dysbiosis with Disease Phenotype and Treatment in Systemic Lupus Erythematosus.","description":"<b>Introduction</b>: Gut dysbiosis has been associated with the development of autoimmune diseases, including systemic lupus erythematosus (SLE). Although previous studies suggest microbial alterations in SLE, evidence at the species level and its clinical relevance remain limited. This study aimed to characterise the gut microbiota at species level in SLE patients and evaluate its association with clinical features. <b>Materials and methods</b>: A total of 57 SLE patients and 57 matched controls were included. Faecal samples were collected using the OMNIgene-GUT kit, and microbial DNA was extracted with the Maxwell RSC PureFood GMO kit. Metagenomic sequencing was performed using the Illumina MiSeq platform, and the data was analysed with QIIME2. Microbial diversity and relative abundance ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-30T03:16:03.771Z","creation":"2026-04-30T03:11:18.694Z"},"accession":"S-EPMC12452298","cross_references":{"pubmed":["40981149"],"doi":["10.3390/medsci13030151"]}}