biostudies-literatureRan MHealth Commission of Sichuan ProvinceNational Key R&D Program of the Chinese Science & Technology DepartmentScience and Technology Department of Sichuan ProvinceNational Natural Science Foundation of ChinaScience and Technology Department of Chengdu2560339https://www.ebi.ac.uk/biostudies/studies/S-EPMC12452479biostudies-literatureUnknown20(1)This study aimed to explore the association between ACMSD methylation level in peripheral blood and brain dynamic functional connectivity (dFC) patterns in adolescents with MDD. Sixty-seven drug-naive, first-episode adolescents with MDD (mean age 14.55 ± 1.38 years, 24 males [35.8%]) and twenty-three healthy controls (HCs, mean age 14.34 ± 1.47 years, 10 males [43.5%]) completed resting-state structural and functional magnetic resonance imaging. DNA samples were collected from peripheral venous blood. Joint and Individual Variation Explained (JIVE) method was used to explore the joint and independent components of four domains of environmental factors (life adverse events, LAE; family environment, FE; family functioning, FF; childhood chronic stress, CCS). Dynamic independent component anaEpigeneticsACMSD methylation in peripheral blood is associated with dynamic functional connectivity pattern in adolescent MDD patients.PMC124524792019-YF05-00284-SN818013572022YFS035121PJ0202023YFE0118600Tao YFu XZhang HJin MZou SXu HDeng FRan MWang ZYin LTang XfalseACMSD methylation in peripheral blood is associated with dynamic functional connectivity pattern in adolescent MDD patients.This study aimed to explore the association between ACMSD methylation level in peripheral blood and brain dynamic functional connectivity (dFC) patterns in adolescents with MDD. Sixty-seven drug-naive, first-episode adolescents with MDD (mean age 14.55 ± 1.38 years, 24 males [35.8%]) and twenty-three healthy controls (HCs, mean age 14.34 ± 1.47 years, 10 males [43.5%]) completed resting-state structural and functional magnetic resonance imaging. DNA samples were collected from peripheral venous blood. Joint and Individual Variation Explained (JIVE) method was used to explore the joint and independent components of four domains of environmental factors (life adverse events, LAE; family environment, FE; family functioning, FF; childhood chronic stress, CCS). Dynamic independent component ana2025-01-01T00:00:00Z2025 Dec2026-06-03T19:10:52.435Z2026-04-30T03:11:58.379ZS-EPMC124524794096083810.1080/15592294.2025.2560339