{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bauer-Rowe KE"],"funding":["NIH National Institute of General Medical Sciences","NIDCR NIH HHS","National Institutes of Health Office of Research Infrastructure Programs","Sarnoff Cardiovascular Research Foundation","National Institutes of Health","National Institutes of Health National Institute of Allergy and Infectious Diseases","American Surgical Association Foundation","Burroughs Wellcome Fund","National Institute of Dental and Craniofacial Research","Digestive Diseases Reseach Core Center, University of Chicago","California Institute for Regenerative Medicine","NIAMS NIH HHS","NIH HHS","Digestive Diseases Research Core Center, University of Chicago","National Institute of Arthritis and Musculoskeletal and Skin Diseases","New York Stem Cell Foundation","PEW Charitable Trusts","National Institute of Diabetes and Digestive and Kidney Diseases","American College of Surgeons","NIAID NIH HHS","NIDDK NIH HHS","Scleroderma Research Foundation","NIGMS NIH HHS","Stanford Maternal and Child Health Research Institute","Reed Foundation"],"pagination":["6536-6553.e26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12453597"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["188(23)"],"pubmed_abstract":["A significant complication of Crohn's disease (CD) is intestinal fibrosis, which narrows the bowel lumen to form a stricture. Creeping fat (CF) is the wrapping of mesenteric adipose tissue around diseased bowel, of which the role in CD stricture progression is unclear. By constructing a human single-cell CD fibroblast atlas, we identified CF-derived, CTHRC1+ fibroblasts enriched for Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) signatures and localized to a fibrotic CF-bowel wall interface within the stricture. We further showed that analogous Cthrc1+ mouse fibroblasts derive from mesenteric adipose tissue stromal cells, infiltrate fibrotic bowel, and deposit extracellular matrix in a YAP/TAZ-dependent manner in a mouse model of intestinal fibrosis."],"journal":["Cell"],"pubmed_title":["Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn's disease strictures."],"pmcid":["PMC12453597"],"funding_grant_id":["R01 AR081343","R01 DE032677","R01 GM136659","R01 AI184905","U24 DE029463","P30 DK097948","RO1 DK 125293","R01-DE032677","R01-AR081343","S10-OD016164","T32 GM145402","R01-GM136659","R01AI184905","R01 DE021683","R01 DK125293","S10 OD016164","R01 AI168462","00034119","R01AI168462","U24DE029463"],"pubmed_authors":["Sidhu I","Naik SL","Longaker MT","Hyun JS","Kim A","Foster DS","Pizarro TT","Wan DC","Xing Y","Goyal A","Guo JL","Bauer-Rowe KE","Pham B","Liang NE","Prystupa A","Korah M","Januszyk M","Norton JA","Griffin M","Suh EJ","Lu JM","De Santis S","Delitto D"],"additional_accession":[]},"is_claimable":false,"name":"Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn's disease strictures.","description":"A significant complication of Crohn's disease (CD) is intestinal fibrosis, which narrows the bowel lumen to form a stricture. Creeping fat (CF) is the wrapping of mesenteric adipose tissue around diseased bowel, of which the role in CD stricture progression is unclear. By constructing a human single-cell CD fibroblast atlas, we identified CF-derived, CTHRC1+ fibroblasts enriched for Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) signatures and localized to a fibrotic CF-bowel wall interface within the stricture. We further showed that analogous Cthrc1+ mouse fibroblasts derive from mesenteric adipose tissue stromal cells, infiltrate fibrotic bowel, and deposit extracellular matrix in a YAP/TAZ-dependent manner in a mouse model of intestinal fibrosis.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-13T05:08:22.283Z","creation":"2026-06-13T03:09:04.627Z"},"accession":"S-EPMC12453597","cross_references":{"pubmed":["40967215"],"doi":["10.1016/j.cell.2025.08.029"]}}