{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen W"],"funding":["Intramural NIH HHS"],"pagination":["483-512"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12453633"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41"],"pubmed_abstract":["Transforming growth factor β (TGF-β) is a key cytokine regulating the development, activation, proliferation, differentiation, and death of T cells. In CD4<sup>+</sup> T cells, TGF-β maintains the quiescence and controls the activation of naive T cells. While inhibiting the differentiation and function of Th1 and Th2 cells, TGF-β promotes the differentiation of Th17 and Th9 cells. TGF-β is required for the induction of Foxp3 in naive T cells and the development of regulatory T cells. TGF-β is crucial in the differentiation of tissue-resident memory CD8<sup>+</sup> T cells and their retention in the tissue, whereas it suppresses effector T cell function. In addition, TGF-β also regulates the generation or function of natural killer T cells, γδ T cells, innate lymphoid cells, and gut intraep"],"journal":["Annual review of immunology"],"pubmed_title":["TGF-β Regulation of T Cells."],"pmcid":["PMC12453633"],"funding_grant_id":["Z01 DE000101"],"pubmed_authors":["Chen W"],"additional_accession":[]},"is_claimable":false,"name":"TGF-β Regulation of T Cells.","description":"Transforming growth factor β (TGF-β) is a key cytokine regulating the development, activation, proliferation, differentiation, and death of T cells. In CD4<sup>+</sup> T cells, TGF-β maintains the quiescence and controls the activation of naive T cells. While inhibiting the differentiation and function of Th1 and Th2 cells, TGF-β promotes the differentiation of Th17 and Th9 cells. TGF-β is required for the induction of Foxp3 in naive T cells and the development of regulatory T cells. TGF-β is crucial in the differentiation of tissue-resident memory CD8<sup>+</sup> T cells and their retention in the tissue, whereas it suppresses effector T cell function. In addition, TGF-β also regulates the generation or function of natural killer T cells, γδ T cells, innate lymphoid cells, and gut intraep","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-06-03T19:11:06.281Z","creation":"2026-04-30T03:12:01.075Z"},"accession":"S-EPMC12453633","cross_references":{"pubmed":["36750317"],"doi":["10.1146/annurev-immunol-101921-045939"]}}