biostudies-literatureShuang NINatural Science Foundation-funded Project: Mechanism of Tiaogeng Decoction improving Cognitive Function via Regulating Nuclear Factor-erythroid 2-related Factor 2/c-Jun N-terminal kinase/Aβ Oxidative Stress Network in Hippocampus Neurons987-997https://www.ebi.ac.uk/biostudies/studies/S-EPMC12453984biostudies-literatureUnknown45(5)<h4>Objective</h4>To explore the mechanism of action of Tiaogeng decoction (, TG) in alleviating oxidative stress damage in the hippocampus of a mouse model of cognitive impairment.<h4>Methods</h4>Amyloid precursor protein/presenilin-1 (APP/PS1) transgenic female mice were randomly divided into model, estradiol valerate, low-, medium-, and high-dose TG groups, female C57 mice were used as the control group (<i>n</i> = 12/group). After 12 weeks of treatment, the behavior of mice was tested with the Morris water maze, and brain tissue samples were collected, and changes in hippocampal neurons were observed using electron microscopy. The deposition of beta-amyloid protein (Aβ) amyloid plaques in the hippocampus was determined by light microscopy. Aβ1-42 protein levels were detected through imJournal of traditional Chinese medicine = Chung i tsa chih ying wen panMechanism of Tiaogeng decoction in a cognitive dysfunction mouse model.PMC1245398481874482Xiaoyan GZuxi GULianwei XUXiaofei LShengnan LIShuang NIXianwei GPanqing WUChao CfalseMechanism of Tiaogeng decoction in a cognitive dysfunction mouse model.<h4>Objective</h4>To explore the mechanism of action of Tiaogeng decoction (, TG) in alleviating oxidative stress damage in the hippocampus of a mouse model of cognitive impairment.<h4>Methods</h4>Amyloid precursor protein/presenilin-1 (APP/PS1) transgenic female mice were randomly divided into model, estradiol valerate, low-, medium-, and high-dose TG groups, female C57 mice were used as the control group (<i>n</i> = 12/group). After 12 weeks of treatment, the behavior of mice was tested with the Morris water maze, and brain tissue samples were collected, and changes in hippocampal neurons were observed using electron microscopy. The deposition of beta-amyloid protein (Aβ) amyloid plaques in the hippocampus was determined by light microscopy. Aβ1-42 protein levels were detected through im2025-01-01T00:00:00Z2025 Oct2026-06-10T05:21:27.598Z2026-06-10T03:07:30.537ZS-EPMC124539844101579710.19852/j.cnki.jtcm.2025.05.006