{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Z"],"funding":["Natural Science Foundation of Guangdong Province: the Role of the Neuropeptide Spexin-associated Gycogen Synthase Kinase-3β Signaling Pathway in Regulating the Enteric Nervous-immune Network in Ulcerative Colitis and the Intervention Mechanism of Chang'an Formula","National Natural Science Foundation of China: Mechanism of Chang'an Decoction in Intestinal Mucosal Immunity of Ulcerative Colitis on Exocrine Mediated Rab27"],"pagination":["998-1008"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12453985"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(5)"],"pubmed_abstract":["Objective
To explore the effect of Chang'an decoction (, CAD) of ameliorating the immune imbalances in ulcerative colitis (UC) by regulating Rab27 in the P53/high mobility group box 1 pathway.Methods
The functions and important signaling pathways of the Rab27- and UC-related genes were analyzed viathe use of microarray data from the gene expression omnibus database, gene ontology database, Kyoto encyclopedia of genes and genomes database and gene set enrichment analysis. Dextran sulfate sodium salt-induced colitis mouse model was used to verify the bioinformatics results. Colon length, body weight, and disease activity index were measured. Hematoxylin and eosin staining was applied to validate the histopathology. Tight junction proteins were detected by immunohistoch"],"journal":["Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan"],"pubmed_title":["Effect of Chang'an decoction on ulcerative colitis by regulating T helper 17 cells and regulatory T cellsRab27 in the p53/high mobility group box 1 pathway."],"pmcid":["PMC12453985"],"funding_grant_id":["81903963","2018A030310614"],"pubmed_authors":["Li Z","Yingqi W","Hong MI","Ting J","Xiaojing W","Fengbin L"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Chang'an decoction on ulcerative colitis by regulating T helper 17 cells and regulatory T cellsRab27 in the p53/high mobility group box 1 pathway.","description":"Objective
To explore the effect of Chang'an decoction (, CAD) of ameliorating the immune imbalances in ulcerative colitis (UC) by regulating Rab27 in the P53/high mobility group box 1 pathway.Methods
The functions and important signaling pathways of the Rab27- and UC-related genes were analyzed viathe use of microarray data from the gene expression omnibus database, gene ontology database, Kyoto encyclopedia of genes and genomes database and gene set enrichment analysis. Dextran sulfate sodium salt-induced colitis mouse model was used to verify the bioinformatics results. Colon length, body weight, and disease activity index were measured. Hematoxylin and eosin staining was applied to validate the histopathology. Tight junction proteins were detected by immunohistoch","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-11T05:03:52.245Z","creation":"2026-06-11T03:07:59.658Z"},"accession":"S-EPMC12453985","cross_references":{"pubmed":["41015798"],"doi":["10.19852/j.cnki.jtcm.2025.05.007"]}}