{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tingyu P"],"funding":["Intra-hospital Fund of Jiangsu Provincial Hospital of Traditional Chinese Medicine Development","Traditional Chinese Medicine Science and Technology Development Plan of Jiangsu Province"],"pagination":["1009-1018"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12453992"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(5)"],"pubmed_abstract":["<h4>Objective</h4>To investigate the mechanisms of the effect of Shenji Guben (SJGB) decoction on chronic obstructive pulmonary disease (COPD).<h4>Methods</h4>A murine model of COPD was established through lipopolysaccharide (LPS) nasal drops and passive smoke exposure, followed by evaluation of SJGB decoction efficacy <i>via</i> lung function tests and histological analysis. Non-targeted liquid chromatography-mass spectrometry (LC-MS)-based metabolomics was used to explore the mechanisms of SJGB decoction in COPD.<h4>Results</h4>We found that the SJGB decoction effectively reduced inflammatory cell infiltration in the airways and lungs, and improved lung function in the COPD model mice. LC-MS-based metabolomics identified 86 biomarkers in COPD models. Compared to the model group, SJGB dec"],"journal":["Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan"],"pubmed_title":["Liquid chromatography-mass spectrometry-based metabolomics study of the protective mechanism of Shenji Guben decoction on chronic obstructive pulmonary disease."],"pmcid":["PMC12453992"],"funding_grant_id":["MS2021013","Y2021ZR11","ZD202215"],"pubmed_authors":["Tingyu P","Jing Y","Jieyu WU","Shuang Y","Zikai S","Yu W","Hailang HE","Yue GE","Yong XU","Xianmei Z"],"additional_accession":[]},"is_claimable":false,"name":"Liquid chromatography-mass spectrometry-based metabolomics study of the protective mechanism of Shenji Guben decoction on chronic obstructive pulmonary disease.","description":"<h4>Objective</h4>To investigate the mechanisms of the effect of Shenji Guben (SJGB) decoction on chronic obstructive pulmonary disease (COPD).<h4>Methods</h4>A murine model of COPD was established through lipopolysaccharide (LPS) nasal drops and passive smoke exposure, followed by evaluation of SJGB decoction efficacy <i>via</i> lung function tests and histological analysis. Non-targeted liquid chromatography-mass spectrometry (LC-MS)-based metabolomics was used to explore the mechanisms of SJGB decoction in COPD.<h4>Results</h4>We found that the SJGB decoction effectively reduced inflammatory cell infiltration in the airways and lungs, and improved lung function in the COPD model mice. LC-MS-based metabolomics identified 86 biomarkers in COPD models. Compared to the model group, SJGB dec","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-11T05:03:47.124Z","creation":"2026-06-11T03:07:58.124Z"},"accession":"S-EPMC12453992","cross_references":{"pubmed":["41015799"],"doi":["10.19852/j.cnki.jtcm.20250327.001"]}}