biostudies-literatureTingyu PIntra-hospital Fund of Jiangsu Provincial Hospital of Traditional Chinese Medicine DevelopmentTraditional Chinese Medicine Science and Technology Development Plan of Jiangsu Province1009-1018https://www.ebi.ac.uk/biostudies/studies/S-EPMC12453992biostudies-literatureUnknown45(5)<h4>Objective</h4>To investigate the mechanisms of the effect of Shenji Guben (SJGB) decoction on chronic obstructive pulmonary disease (COPD).<h4>Methods</h4>A murine model of COPD was established through lipopolysaccharide (LPS) nasal drops and passive smoke exposure, followed by evaluation of SJGB decoction efficacy <i>via</i> lung function tests and histological analysis. Non-targeted liquid chromatography-mass spectrometry (LC-MS)-based metabolomics was used to explore the mechanisms of SJGB decoction in COPD.<h4>Results</h4>We found that the SJGB decoction effectively reduced inflammatory cell infiltration in the airways and lungs, and improved lung function in the COPD model mice. LC-MS-based metabolomics identified 86 biomarkers in COPD models. Compared to the model group, SJGB decJournal of traditional Chinese medicine = Chung i tsa chih ying wen panLiquid chromatography-mass spectrometry-based metabolomics study of the protective mechanism of Shenji Guben decoction on chronic obstructive pulmonary disease.PMC12453992MS2021013Y2021ZR11ZD202215Tingyu PJing YJieyu WUShuang YZikai SYu WHailang HEYue GEYong XUXianmei ZfalseLiquid chromatography-mass spectrometry-based metabolomics study of the protective mechanism of Shenji Guben decoction on chronic obstructive pulmonary disease.<h4>Objective</h4>To investigate the mechanisms of the effect of Shenji Guben (SJGB) decoction on chronic obstructive pulmonary disease (COPD).<h4>Methods</h4>A murine model of COPD was established through lipopolysaccharide (LPS) nasal drops and passive smoke exposure, followed by evaluation of SJGB decoction efficacy <i>via</i> lung function tests and histological analysis. Non-targeted liquid chromatography-mass spectrometry (LC-MS)-based metabolomics was used to explore the mechanisms of SJGB decoction in COPD.<h4>Results</h4>We found that the SJGB decoction effectively reduced inflammatory cell infiltration in the airways and lungs, and improved lung function in the COPD model mice. LC-MS-based metabolomics identified 86 biomarkers in COPD models. Compared to the model group, SJGB dec2025-01-01T00:00:00Z2025 Oct2026-06-11T05:03:47.124Z2026-06-11T03:07:58.124ZS-EPMC124539924101579910.19852/j.cnki.jtcm.20250327.001