biostudies-literatureUnknown16Chen W<h4>Introduction</h4>Alternative splicing (AS) and RNA-binding proteins (RBPs) have been implicated in various diseases. However, a comprehensive understanding of their role in RNA metabolism, progression, and metastasis in cervical cancer remains elusive. This study aimed to identify the potential effect of zinc finger CCCH-type containing 18 (ZC3H18) in cervical cancer.<h4>Methods</h4>The Gene Expression Omnibus (GEO) dataset (GSE94427) was used to analyze the expression level of ZC3H18 in HeLa cells and its regulated alternative splicing events (ASEs). The Cancer Genome Atlas (TCGA) cervical cancer dataset and in vitro experiments were used for verification. The signaling pathways and functions of ZC3H18-regulated ASEs were investigated through enrichment analysis.<h4>Results</h4>KnockdFrontiers in genetics1621238https://www.ebi.ac.uk/biostudies/studies/S-EPMC12454084biostudies-literatureZC3H18 regulates alternative splicing and related genes in cervical cancer.PMC12454084Hu DLi SXie XChen WLin YLiu CfalseZC3H18 regulates alternative splicing and related genes in cervical cancer.<h4>Introduction</h4>Alternative splicing (AS) and RNA-binding proteins (RBPs) have been implicated in various diseases. However, a comprehensive understanding of their role in RNA metabolism, progression, and metastasis in cervical cancer remains elusive. This study aimed to identify the potential effect of zinc finger CCCH-type containing 18 (ZC3H18) in cervical cancer.<h4>Methods</h4>The Gene Expression Omnibus (GEO) dataset (GSE94427) was used to analyze the expression level of ZC3H18 in HeLa cells and its regulated alternative splicing events (ASEs). The Cancer Genome Atlas (TCGA) cervical cancer dataset and in vitro experiments were used for verification. The signaling pathways and functions of ZC3H18-regulated ASEs were investigated through enrichment analysis.<h4>Results</h4>Knockd2025-01-01T00:00:00Z20252026-06-03T20:05:36.253Z2026-05-01T03:11:00.193ZS-EPMC124540844099543110.3389/fgene.2025.1621238