biostudies-literatureXiaosi ZFundamental Research Funds for the Central Universities: Research on the Mechanism of Hewei Jiangni Recipe on Nonerosive Gastroesophageal Reflux Based on the Correlation Analysis of Gut Microbiota and MetabolitesNational Natural Science Foundation of China: Exploring the Molecular Mechanism of "Hewei Jiangni Fang" Intervention in Non-erosive Reflux Disease Esophageal Hypersensitivity from the Perspective of Mas-related Gene X2/Stromal Interaction Molecule 1/Cell Adhesion Molecule 1 Pathway Regulation of Mast Cell/Dorsal Root Ganglion Communication Based on the "Xinkai-Kujiang" Method1106-1118https://www.ebi.ac.uk/biostudies/studies/S-EPMC12454263biostudies-literatureUnknown45(5)<h4>Objective</h4>To evaluate the safety and efficacy of Hewei Jiangni recipe (, HWJNR) for treating nonerosive gastroesophageal reflux (NERD) with cold-heat complex syndrome and to clarify its mechanism based on correlation analyses of intestinal flora and metabolites.<h4>Methods</h4>Seventy-two patients with NERD and the Traditional Chinese Medicine (TCM) syndrome of intermingled heat and cold were randomly assigned to either the TCM group or the Western Medicine group, each receiving 8 weeks of treatment. The primary outcome was the score of the gastroesophageal reflux disease questionnaire (GERD-Q). Additionally, 10 healthy individuals were recruited. Mechanistic outcomes included correlation analyses of intestinal flora and metabolites in healthy individuals and NERD participants befoJournal of traditional Chinese medicine = Chung i tsa chih ying wen panHewei Jiangni recipe improved the quality of life in patients with cold-heat mixed nonerosive reflux disease: a randomized, double-blinded study.PMC124542632020-JYB-ZDGG-12882374401Xiaosi ZChune XXiaohong LIHanqing CJunxiang LIShuangyuan ZZhengdao LfalseHewei Jiangni recipe improved the quality of life in patients with cold-heat mixed nonerosive reflux disease: a randomized, double-blinded study.<h4>Objective</h4>To evaluate the safety and efficacy of Hewei Jiangni recipe (, HWJNR) for treating nonerosive gastroesophageal reflux (NERD) with cold-heat complex syndrome and to clarify its mechanism based on correlation analyses of intestinal flora and metabolites.<h4>Methods</h4>Seventy-two patients with NERD and the Traditional Chinese Medicine (TCM) syndrome of intermingled heat and cold were randomly assigned to either the TCM group or the Western Medicine group, each receiving 8 weeks of treatment. The primary outcome was the score of the gastroesophageal reflux disease questionnaire (GERD-Q). Additionally, 10 healthy individuals were recruited. Mechanistic outcomes included correlation analyses of intestinal flora and metabolites in healthy individuals and NERD participants befo2025-01-01T00:00:00Z2025 Oct2026-06-11T05:03:50.65Z2026-06-11T03:07:59.446ZS-EPMC124542634101580910.19852/j.cnki.jtcm.20250107.001