biostudies-literatureUnknown5(1)Li C<h4>Background</h4>Existing literature on serum cholinesterase (ChE) in cancer prognosis have predominantly evaluated preoperative levels, ignoring serial ChE measurements during postoperative follow-up.<h4>Methods</h4>5925 patients undergoing curative resection for stage I-III non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and gastric cancer (GC) were retrospectively included. Patients were divided into persistently normal, normalized, lowered and persistently low perioperative ChE patterns, as well as longitudinal ChE trajectories identified by the latent class growth mixed model (LCGMM). The associations of ChE dynamic changes with overall survival (OS) and recurrence-free survival (RFS) were evaluated.<h4>Results</h4>Postoperative ChE emerged as an independent prognostic Communications medicine391https://www.ebi.ac.uk/biostudies/studies/S-EPMC12454652biostudies-literatureLongitudinal evaluation of serum cholinesterase benefits prognosis surveillance of common types of human cancer.PMC12454652Lv JLi YLi ZZhang TLi CLiu LYou DYou RFan BfalseLongitudinal evaluation of serum cholinesterase benefits prognosis surveillance of common types of human cancer.<h4>Background</h4>Existing literature on serum cholinesterase (ChE) in cancer prognosis have predominantly evaluated preoperative levels, ignoring serial ChE measurements during postoperative follow-up.<h4>Methods</h4>5925 patients undergoing curative resection for stage I-III non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and gastric cancer (GC) were retrospectively included. Patients were divided into persistently normal, normalized, lowered and persistently low perioperative ChE patterns, as well as longitudinal ChE trajectories identified by the latent class growth mixed model (LCGMM). The associations of ChE dynamic changes with overall survival (OS) and recurrence-free survival (RFS) were evaluated.<h4>Results</h4>Postoperative ChE emerged as an independent prognostic 2025-01-01T00:00:00Z2025 Sep2026-06-03T18:52:45.074Z2026-04-30T03:11:36.243ZS-EPMC124546524098367410.1038/s43856-025-01133-w