{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hakkar R"],"funding":["Agence Nationale de la Recherche","NCI NIH HHS"],"pagination":["e70164"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12454923"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(9)"],"pubmed_abstract":["Extracellular vesicles (EVs) represent a cytokine-independent pathway though which skeletal muscle (SkM) cells influence the fate of neighbouring cells, thereby regulating SkM metabolic homeostasis and regeneration. Although SkM-EVs are increasingly being explored as a therapeutic strategy to enhance muscle regeneration or to induce the myogenic differentiation of induced pluripotent stem cells (iPSCs), the mechanisms governing their release from muscle cells remain poorly described. Moreover, because muscle regeneration involves a tightly regulated inflammatory response it also important to determine how inflammation alters SkM-EV cargo and function in order to design more effective EV-based therapies. To address this knowledge gap, we isolated and characterized the large and small EVs (l"],"journal":["Journal of extracellular vesicles"],"pubmed_title":["Sphingolipids in Extracellular Vesicles Released From the Skeletal Muscle Plasma Membrane Control Muscle Stem Cell Fate During Muscle Regeneration."],"pmcid":["PMC12454923"],"funding_grant_id":["R50 CA283661","ANR-21-CE14-617 0081","ANR-22-CE14-0070","ANR-20-CE18-0026"],"pubmed_authors":["Larcher T","Weaver A","Sung BH","Bouzakri K","Leblanc P","Calzada C","Hakkar R","Errazuriz-Cerda E","de Barros JP","Cassin C","Bongiovanni A","Berger-Danty E","Blanc-Brude O","Pesenti S","Pichon J","Reininger L","Jalabert A","Rouger K","Vasan SB","Rome S","Gache V","Meugnier E","Tacconi S","Brun CE"],"additional_accession":[]},"is_claimable":false,"name":"Sphingolipids in Extracellular Vesicles Released From the Skeletal Muscle Plasma Membrane Control Muscle Stem Cell Fate During Muscle Regeneration.","description":"Extracellular vesicles (EVs) represent a cytokine-independent pathway though which skeletal muscle (SkM) cells influence the fate of neighbouring cells, thereby regulating SkM metabolic homeostasis and regeneration. Although SkM-EVs are increasingly being explored as a therapeutic strategy to enhance muscle regeneration or to induce the myogenic differentiation of induced pluripotent stem cells (iPSCs), the mechanisms governing their release from muscle cells remain poorly described. Moreover, because muscle regeneration involves a tightly regulated inflammatory response it also important to determine how inflammation alters SkM-EV cargo and function in order to design more effective EV-based therapies. To address this knowledge gap, we isolated and characterized the large and small EVs (l","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T18:49:21.026Z","creation":"2026-04-30T03:11:33.548Z"},"accession":"S-EPMC12454923","cross_references":{"pubmed":["40984725"],"doi":["10.1002/jev2.70164"]}}