{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao P"],"funding":["National Natural Science Foundation of China","Beijing Natural Science Foundation"],"pagination":["0895"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12454940"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["T lymphocyte dysfunction represents a pivotal determinant of immunosuppression in sepsis. Our previous studies demonstrated that nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)-mediated ribophagy conferred cytoprotection against apoptosis in CD4<sup>+</sup> T lymphocytes during sepsis, thereby preserving host immunocompetence. Despite growing evidence linking PANoptosis to the pathogenesis of various diseases, the potential role of ribophagy in modulating CD4<sup>+</sup> T lymphocytes' PANoptosis in sepsis remains largely unclear. In the present study, we employed both lipopolysaccharide-stimulated Jurkat T cells and cecal ligation and puncture (CLP)-induced sepsis models to demonstrate marked exacerbation of CD4<sup>+</sup> T lymphocyte PANoptosis following <i>NUFIP1</"],"journal":["Research (Washington, D.C.)"],"pubmed_title":["NUFIP1-Mediated Ribophagy Alleviates PANoptosis of CD4&lt;sup&gt;+&lt;/sup&gt; T Lymphocytes in Sepsis via the cGAS-STING Pathway."],"pmcid":["PMC12454940"],"funding_grant_id":["Nos. 82130062, 82241062, 82372158","7244296"],"pubmed_authors":["Xia Y","Chen N","Yang J","Li J","Luo Z","Fu Z","Du X","Yao R","Dong N","He P","Yang X","Yao Y","Zhao P","Zheng L","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"NUFIP1-Mediated Ribophagy Alleviates PANoptosis of CD4&lt;sup&gt;+&lt;/sup&gt; T Lymphocytes in Sepsis via the cGAS-STING Pathway.","description":"T lymphocyte dysfunction represents a pivotal determinant of immunosuppression in sepsis. Our previous studies demonstrated that nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)-mediated ribophagy conferred cytoprotection against apoptosis in CD4<sup>+</sup> T lymphocytes during sepsis, thereby preserving host immunocompetence. Despite growing evidence linking PANoptosis to the pathogenesis of various diseases, the potential role of ribophagy in modulating CD4<sup>+</sup> T lymphocytes' PANoptosis in sepsis remains largely unclear. In the present study, we employed both lipopolysaccharide-stimulated Jurkat T cells and cecal ligation and puncture (CLP)-induced sepsis models to demonstrate marked exacerbation of CD4<sup>+</sup> T lymphocyte PANoptosis following <i>NUFIP1</","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-31T03:11:39.628Z","creation":"2026-05-31T03:07:56.537Z"},"accession":"S-EPMC12454940","cross_references":{"pubmed":["40995563"],"doi":["10.34133/research.0895"]}}