biostudies-literatureZhao PNational Natural Science Foundation of ChinaBeijing Natural Science Foundation0895https://www.ebi.ac.uk/biostudies/studies/S-EPMC12454940biostudies-literatureUnknown8T lymphocyte dysfunction represents a pivotal determinant of immunosuppression in sepsis. Our previous studies demonstrated that nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)-mediated ribophagy conferred cytoprotection against apoptosis in CD4⁺ T lymphocytes during sepsis, thereby preserving host immunocompetence. Despite growing evidence linking PANoptosis to the pathogenesis of various diseases, the potential role of ribophagy in modulating CD4⁺ T lymphocytes' PANoptosis in sepsis remains largely unclear. In the present study, we employed both lipopolysaccharide-stimulated Jurkat T cells and cecal ligation and puncture (CLP)-induced sepsis models to demonstrate marked exacerbation of CD4⁺ T lymphocyte PANoptosis following <i>NUFIP1</Research (Washington, D.C.)NUFIP1-Mediated Ribophagy Alleviates PANoptosis of CD4&lt;sup&gt;+&lt;/sup&gt; T Lymphocytes in Sepsis via the cGAS-STING Pathway.PMC12454940Nos. 82130062, 82241062, 823721587244296Xia YChen NYang JLi JLuo ZFu ZDu XYao RDong NHe PYang XYao YZhao PZheng LWu YfalseNUFIP1-Mediated Ribophagy Alleviates PANoptosis of CD4&lt;sup&gt;+&lt;/sup&gt; T Lymphocytes in Sepsis via the cGAS-STING Pathway.T lymphocyte dysfunction represents a pivotal determinant of immunosuppression in sepsis. Our previous studies demonstrated that nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)-mediated ribophagy conferred cytoprotection against apoptosis in CD4⁺ T lymphocytes during sepsis, thereby preserving host immunocompetence. Despite growing evidence linking PANoptosis to the pathogenesis of various diseases, the potential role of ribophagy in modulating CD4⁺ T lymphocytes' PANoptosis in sepsis remains largely unclear. In the present study, we employed both lipopolysaccharide-stimulated Jurkat T cells and cecal ligation and puncture (CLP)-induced sepsis models to demonstrate marked exacerbation of CD4⁺ T lymphocyte PANoptosis following <i>NUFIP1</2025-01-01T00:00:00Z20252026-05-31T03:11:39.628Z2026-05-31T03:07:56.537ZS-EPMC124549404099556310.34133/research.0895