biostudies-literatureWu TTianjin Health Research ProjectInternational Cooperation and Exchange ProgrammeTianjin Key Medical Discipline (Specialty) Construction Project1813-1822https://www.ebi.ac.uk/biostudies/studies/S-EPMC12455873biostudies-literatureUnknown12(9)<h4>Objective</h4>Glial fibrillary acidic protein astrocytopathy (GFAP-A) is a recently defined nosological form belonging to the class of autoimmune inflammatory disorders affecting the central nervous system (CNS). Here, we report the clinical and MRI characteristics, treatment, and prognosis of a GFAP-A cohort from two centers in China.<h4>Methods</h4>We retrospectively analyzed the data from 38 adult patients with positive GFAP antibodies and diagnosed as GFAP-A between June 2019 and September 2024. Clinical features, semiquantitative antibody test results, MRI features, treatment approaches, and prognosis were collected.<h4>Results</h4>Among the 38 patients, 24 were male, and the median age at disease onset was 49.5 years. The clinical phenotype included encephalomyelitis (28.9%), myeAnnals of clinical and translational neurologyGlial Fibrillary Acidic Protein Astrocytopathy Based on a Two-Center Chinese Cohort Study.PMC12455873TJYXZDXK-004A82320108007TJWJ2023QN019Shi FDZhang HYu QZhang LJFan MCong HWei YBottcher CGao CVerkhratsky ASong TWu TPaul FfalseGlial Fibrillary Acidic Protein Astrocytopathy Based on a Two-Center Chinese Cohort Study.<h4>Objective</h4>Glial fibrillary acidic protein astrocytopathy (GFAP-A) is a recently defined nosological form belonging to the class of autoimmune inflammatory disorders affecting the central nervous system (CNS). Here, we report the clinical and MRI characteristics, treatment, and prognosis of a GFAP-A cohort from two centers in China.<h4>Methods</h4>We retrospectively analyzed the data from 38 adult patients with positive GFAP antibodies and diagnosed as GFAP-A between June 2019 and September 2024. Clinical features, semiquantitative antibody test results, MRI features, treatment approaches, and prognosis were collected.<h4>Results</h4>Among the 38 patients, 24 were male, and the median age at disease onset was 49.5 years. The clinical phenotype included encephalomyelitis (28.9%), mye2025-01-01T00:00:00Z2025 Sep2026-06-03T19:07:22.522Z2026-04-30T03:12:09.07ZS-EPMC124558734064109410.1002/acn3.70118