biostudies-literatureHan SNIDDK NIH HHSNational Institute of Diabetes and Digestive and Kidney Diseasese00888https://www.ebi.ac.uk/biostudies/studies/S-EPMC12456583biostudies-literatureUnknown16(9)<h4>Introduction</h4>Chronic pancreatitis (CP) remains difficult to manage with few treatment options. Prior studies have implicated prostaglandin E 2 (PGE 2 ) in mediating chronic inflammation in the pancreas. Therefore, we aimed to evaluate whether indomethacin, a cyclooxygenase-2 enzyme inhibitor, would reduce PGE 2 levels in CP.<h4>Methods</h4>In this pilot multicenter randomized controlled trial, participants with CP received oral indomethacin (50 mg) or placebo twice daily for 28 days. Measurement of PGE 2 levels in pancreatic fluid collected endoscopically after secretin administration at baseline and posttreatment (day 28) was performed. Quality of life and pain were also assessed at baseline and posttreatment.<h4>Results</h4>A total of 27 participants were randomized (indomethacinClinical and translational gastroenterologyOral Indomethacin for Chronic Pancreatitis: Results From the PAIR Randomized Placebo-Controlled Trial.PMC12456583R21 DK117212R21DK117212Saloman JLCruz-Monserrate ZHill RHao WYadav DHan SLi LXu JConwell DLHart PAVege SSTopazian MPalermo TMfalseOral Indomethacin for Chronic Pancreatitis: Results From the PAIR Randomized Placebo-Controlled Trial.<h4>Introduction</h4>Chronic pancreatitis (CP) remains difficult to manage with few treatment options. Prior studies have implicated prostaglandin E 2 (PGE 2 ) in mediating chronic inflammation in the pancreas. Therefore, we aimed to evaluate whether indomethacin, a cyclooxygenase-2 enzyme inhibitor, would reduce PGE 2 levels in CP.<h4>Methods</h4>In this pilot multicenter randomized controlled trial, participants with CP received oral indomethacin (50 mg) or placebo twice daily for 28 days. Measurement of PGE 2 levels in pancreatic fluid collected endoscopically after secretin administration at baseline and posttreatment (day 28) was performed. Quality of life and pain were also assessed at baseline and posttreatment.<h4>Results</h4>A total of 27 participants were randomized (indomethacin2025-01-01T00:00:00Z2025 Sep2026-07-15T14:23:02.553Z2026-07-05T03:12:20.212ZS-EPMC124565834062240810.14309/ctg.0000000000000888