{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(9)"],"submitter":["Li L"],"pubmed_abstract":["This retrospective cohort study aimed to characterize diabetes-stratified associations between serum calcium levels and all-cause, cardiovascular (CVD), and cancer mortality, addressing a critical gap in nutritional epidemiology. Leveraging the National Health and Nutrition Examination Survey (NHANES) database, we conducted Cox proportional hazards regression with restricted cubic splines to model non-linear calcium-mortality relationships. Mediation analysis was conducted in diabetes. The T2DM group presented a J-shaped relationship, with relatively stable and low mortality risk at lower calcium concentrations, followed by a significant increase at higher concentrations. In contrast, the group without diabetes exhibited a U-shaped relationship, indicating that both low and high serum calc"],"journal":["Food science & nutrition"],"pagination":["e71034"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12457720"],"repository":["biostudies-literature"],"pubmed_title":["Diabetes-Specific Serum Calcium Thresholds for Mortality Risk: A NHANES Nutritional Epidemiology Study."],"pmcid":["PMC12457720"],"pubmed_authors":["Ran X","Liu S","Li L","Yang S"],"additional_accession":[]},"is_claimable":false,"name":"Diabetes-Specific Serum Calcium Thresholds for Mortality Risk: A NHANES Nutritional Epidemiology Study.","description":"This retrospective cohort study aimed to characterize diabetes-stratified associations between serum calcium levels and all-cause, cardiovascular (CVD), and cancer mortality, addressing a critical gap in nutritional epidemiology. Leveraging the National Health and Nutrition Examination Survey (NHANES) database, we conducted Cox proportional hazards regression with restricted cubic splines to model non-linear calcium-mortality relationships. Mediation analysis was conducted in diabetes. The T2DM group presented a J-shaped relationship, with relatively stable and low mortality risk at lower calcium concentrations, followed by a significant increase at higher concentrations. In contrast, the group without diabetes exhibited a U-shaped relationship, indicating that both low and high serum calc","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T20:20:07.386Z","creation":"2026-05-01T03:10:48.829Z"},"accession":"S-EPMC12457720","cross_references":{"pubmed":["41000256"],"doi":["10.1002/fsn3.71034"]}}