biostudies-literatureUnknown8(9)Wang Q<h4>Importance</h4>Premenstrual disorders (PMDs), including premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), are associated with significant physical and psychological burdens. However, their associations with quality of life (QOL) remain insufficiently studied, particularly with limited consideration of comorbidities and potential confounders.<h4>Objective</h4>To assess the QOL among women with PMDs compared with women without PMDs in Sweden.<h4>Design, setting, and participants</h4>This cross-sectional study included participants from the LifeGene cohort, a population-based longitudinal study with linkage to national health care registers. Participants were women aged 15 to 60 years. Data were collected from October 2009 to May 2018 and analyzed from June 2024 to JJAMA network opene2533823https://www.ebi.ac.uk/biostudies/studies/S-EPMC12457971biostudies-literaturePremenstrual Disorders and Quality of Life in Sweden.PMC12457971Keijser RWang QBertone-Johnson EAleknaviciute JHagg SLu DChen YHysaj EYu HValdimarsdottir UAfalsePremenstrual Disorders and Quality of Life in Sweden.<h4>Importance</h4>Premenstrual disorders (PMDs), including premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), are associated with significant physical and psychological burdens. However, their associations with quality of life (QOL) remain insufficiently studied, particularly with limited consideration of comorbidities and potential confounders.<h4>Objective</h4>To assess the QOL among women with PMDs compared with women without PMDs in Sweden.<h4>Design, setting, and participants</h4>This cross-sectional study included participants from the LifeGene cohort, a population-based longitudinal study with linkage to national health care registers. Participants were women aged 15 to 60 years. Data were collected from October 2009 to May 2018 and analyzed from June 2024 to J2025-01-01T00:00:00Z2025 Sep2026-06-03T18:51:59.067Z2026-04-30T03:11:34.534ZS-EPMC124579714098629910.1001/jamanetworkopen.2025.33823