biostudies-literatureUnknown21(9)Kivisild A<h4>Introduction</h4>We aimed to investigate early differences in sociodemographic factors before the onset of Alzheimer's disease (AD), frontotemporal dementia (FTD), vascular dementia (VaD), and mixed dementia (AD + VaD).<h4>Methods</h4>Lifetime sociodemographic factors were collected from Statistics Finland for 1238 AD, 274 FTD, 343 VaD, and 402 AD + VaD patients with a diagnosis and visit at Kuopio and Oulu University Hospitals between January 2010 and December 2021. Comparisons were performed between dementia groups and matched controls.<h4>Results</h4>All patient groups showed decreased employment status compared to controls already 10 years prior to diagnosis. In particular, individuals with early-onset FTD (EOFTD; 66.9% vs. 77.6%, p < 0.01) and early-onset VaD (EOVaD; 49.0% vs. 76.Alzheimer's & dementia : the journal of the Alzheimer's Associatione70616https://www.ebi.ac.uk/biostudies/studies/S-EPMC12457979biostudies-literatureSociodemographic traits as early indicators of AD, FTD, and VaD up to 10 years before diagnosis.PMC12457979Solje EKivisild ASoppela HLehtonen ATervonen LHeikkinen SAaltonen MHaapasalo AKruger JRinnankoski IKatisko KErvasti KLeppanen LAho KHartikainen PfalseSociodemographic traits as early indicators of AD, FTD, and VaD up to 10 years before diagnosis.<h4>Introduction</h4>We aimed to investigate early differences in sociodemographic factors before the onset of Alzheimer's disease (AD), frontotemporal dementia (FTD), vascular dementia (VaD), and mixed dementia (AD + VaD).<h4>Methods</h4>Lifetime sociodemographic factors were collected from Statistics Finland for 1238 AD, 274 FTD, 343 VaD, and 402 AD + VaD patients with a diagnosis and visit at Kuopio and Oulu University Hospitals between January 2010 and December 2021. Comparisons were performed between dementia groups and matched controls.<h4>Results</h4>All patient groups showed decreased employment status compared to controls already 10 years prior to diagnosis. In particular, individuals with early-onset FTD (EOFTD; 66.9% vs. 77.6%, p < 0.01) and early-onset VaD (EOVaD; 49.0% vs. 76.2025-01-01T00:00:00Z2025 Sep2026-06-03T19:36:23.163Z2026-04-30T03:12:23.454ZS-EPMC124579794099018310.1002/alz.70616