{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Michalak AJ"],"pubmed_abstract":["<h4>Background</h4>Direct electrocortical stimulation (DES) is the clinical gold standard for identifying eloquent cortex and guiding neurosurgical intervention, yet prior intraoperative DES during awake craniotomies have been limited by intraoperative sampling constraints and density-based rather than probabilistic analyses. The probability of typical and atypical cortical organization has not been fully explored, especially in epilepsy populations. We sought to generate a probabilistic atlas of motor, sensory, and language functions using extraoperative DES in a large cohort of patients with epilepsy.<h4>Methods</h4>We retrospectively analyzed 2,124 extraoperative DES trials from 125 patients undergoing intracranial monitoring (2008-2023). Positive and negative trials were mapped to Mont"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.09.15.676264"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12458103"],"repository":["biostudies-literature"],"pubmed_title":["A probabilistic functional atlas based on extraoperative electrocortical stimulation mapping."],"pmcid":["PMC12458103"],"pubmed_authors":["Kazl C","Devinsky O","Yu L","Flinker A","Khalilian-Gourtani A","Resch Z","Morrison C","Doyle W","Friedman D","Dugan P","Michalak AJ","Seedat A","Rozman P"],"additional_accession":[]},"is_claimable":false,"name":"A probabilistic functional atlas based on extraoperative electrocortical stimulation mapping.","description":"<h4>Background</h4>Direct electrocortical stimulation (DES) is the clinical gold standard for identifying eloquent cortex and guiding neurosurgical intervention, yet prior intraoperative DES during awake craniotomies have been limited by intraoperative sampling constraints and density-based rather than probabilistic analyses. The probability of typical and atypical cortical organization has not been fully explored, especially in epilepsy populations. We sought to generate a probabilistic atlas of motor, sensory, and language functions using extraoperative DES in a large cohort of patients with epilepsy.<h4>Methods</h4>We retrospectively analyzed 2,124 extraoperative DES trials from 125 patients undergoing intracranial monitoring (2008-2023). Positive and negative trials were mapped to Mont","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-04T03:22:00.505Z","creation":"2026-05-04T03:14:29.53Z"},"accession":"S-EPMC12458103","cross_references":{"pubmed":["41000648"],"doi":["10.1101/2025.09.15.676264"]}}