{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Appierdo R"],"funding":["NIAMS NIH HHS"],"pubmed_abstract":["We performed a large-scale immunogenomic analysis of ~13,000 transcriptomic profiles from 10 autoimmune diseases, integrating publicly available datasets from both blood and tissue. Using meta-analysis, we identified core immune mechanisms underlying autoimmunity, including strong interferon responses, inflammation, and adaptive immune suppression, alongside disease-specific signatures. To enhance biological interpretability, we derived higher-order immune features - such as cell type proportions, cytokine levels, pathway activity, transcription factor regulation, and miRNA activity - and organized them into 15 coherent immune modules. These modules enabled systematic cross-disease comparisons, revealing shared and distinct immunopathological patterns. The inflammation module, in particula"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.09.12.675833"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12458282"],"repository":["biostudies-literature"],"pubmed_title":["The Integrated Cellular and Molecular Landscape of Autoimmunity."],"pmcid":["PMC12458282"],"funding_grant_id":["P30 AR070155"],"pubmed_authors":["Appierdo R","Pepe G","Sirota M","Helmer-Citterich M","Gherardini PF","Vallania F"],"additional_accession":[]},"is_claimable":false,"name":"The Integrated Cellular and Molecular Landscape of Autoimmunity.","description":"We performed a large-scale immunogenomic analysis of ~13,000 transcriptomic profiles from 10 autoimmune diseases, integrating publicly available datasets from both blood and tissue. Using meta-analysis, we identified core immune mechanisms underlying autoimmunity, including strong interferon responses, inflammation, and adaptive immune suppression, alongside disease-specific signatures. To enhance biological interpretability, we derived higher-order immune features - such as cell type proportions, cytokine levels, pathway activity, transcription factor regulation, and miRNA activity - and organized them into 15 coherent immune modules. These modules enabled systematic cross-disease comparisons, revealing shared and distinct immunopathological patterns. The inflammation module, in particula","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-05T03:13:22.045Z","creation":"2026-05-05T03:12:18.008Z"},"accession":"S-EPMC12458282","cross_references":{"pubmed":["41000680"],"doi":["10.1101/2025.09.12.675833"]}}