{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Albe JR"],"funding":["NIAID NIH HHS"],"pubmed_abstract":["Enhancing regulatory T cell (Treg) function offers a compelling therapeutic strategy for autoimmune disease. Engineered IL-2 muteins selectively expand functional Tregs with minimal impact on other immune cells, but their potential to compromise antiviral immunity remains largely unexplored. Here, we used a murine model of Influenza A virus (Flu) infection to determine how IL-2 mutein shapes T cell responses to respiratory virus infection. IL-2 mutein administration prior to infection suppressed Flu-specific (Flu-sp) CD8 T cell responses and altered their localization and phenotype within the lungs, without affecting bystander CD8 T cells. This suppression correlated with reduced antigen presentation molecule expression on conventional dendritic cells (cDCs) early after infection but did n"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.06.10.658962"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12458323"],"repository":["biostudies-literature"],"pubmed_title":["Divergent effects of a Treg-selective IL-2 mutein on Influenza specific T cell responses."],"pmcid":["PMC12458323"],"funding_grant_id":["R01 AI154773","R21 AI172140"],"pubmed_authors":["Ziegler SF","Weinstein KN","Sarkar S","Chaudhary A","Campbell DJ","Kalia V","Albe JR","Khanna A"],"additional_accession":[]},"is_claimable":false,"name":"Divergent effects of a Treg-selective IL-2 mutein on Influenza specific T cell responses.","description":"Enhancing regulatory T cell (Treg) function offers a compelling therapeutic strategy for autoimmune disease. Engineered IL-2 muteins selectively expand functional Tregs with minimal impact on other immune cells, but their potential to compromise antiviral immunity remains largely unexplored. Here, we used a murine model of Influenza A virus (Flu) infection to determine how IL-2 mutein shapes T cell responses to respiratory virus infection. IL-2 mutein administration prior to infection suppressed Flu-specific (Flu-sp) CD8 T cell responses and altered their localization and phenotype within the lungs, without affecting bystander CD8 T cells. This suppression correlated with reduced antigen presentation molecule expression on conventional dendritic cells (cDCs) early after infection but did n","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-31T03:12:22.114Z","creation":"2026-05-31T03:07:50.808Z"},"accession":"S-EPMC12458323","cross_references":{"pubmed":["41000731"],"doi":["10.1101/2025.06.10.658962"]}}