biostudies-literatureUnknownAlbe JRNIAID NIH HHSEnhancing regulatory T cell (Treg) function offers a compelling therapeutic strategy for autoimmune disease. Engineered IL-2 muteins selectively expand functional Tregs with minimal impact on other immune cells, but their potential to compromise antiviral immunity remains largely unexplored. Here, we used a murine model of Influenza A virus (Flu) infection to determine how IL-2 mutein shapes T cell responses to respiratory virus infection. IL-2 mutein administration prior to infection suppressed Flu-specific (Flu-sp) CD8 T cell responses and altered their localization and phenotype within the lungs, without affecting bystander CD8 T cells. This suppression correlated with reduced antigen presentation molecule expression on conventional dendritic cells (cDCs) early after infection but did nbioRxiv : the preprint server for biology2025.06.10.658962https://www.ebi.ac.uk/biostudies/studies/S-EPMC12458323biostudies-literatureDivergent effects of a Treg-selective IL-2 mutein on Influenza specific T cell responses.PMC12458323R01 AI154773R21 AI172140Ziegler SFWeinstein KNSarkar SChaudhary ACampbell DJKalia VAlbe JRKhanna AfalseDivergent effects of a Treg-selective IL-2 mutein on Influenza specific T cell responses.Enhancing regulatory T cell (Treg) function offers a compelling therapeutic strategy for autoimmune disease. Engineered IL-2 muteins selectively expand functional Tregs with minimal impact on other immune cells, but their potential to compromise antiviral immunity remains largely unexplored. Here, we used a murine model of Influenza A virus (Flu) infection to determine how IL-2 mutein shapes T cell responses to respiratory virus infection. IL-2 mutein administration prior to infection suppressed Flu-specific (Flu-sp) CD8 T cell responses and altered their localization and phenotype within the lungs, without affecting bystander CD8 T cells. This suppression correlated with reduced antigen presentation molecule expression on conventional dendritic cells (cDCs) early after infection but did n2025-01-01T00:00:00Z2025 Sep2026-05-31T03:12:22.114Z2026-05-31T03:07:50.808ZS-EPMC124583234100073110.1101/2025.06.10.658962