{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(9)"],"submitter":["Srinivas N"],"pubmed_abstract":["<h4>Background</h4>The presence of tertiary lymphoid structures (TLS) in solid tumors, including Merkel cell carcinoma (MCC), is associated with a better prognosis and a better response to immunotherapy with immune checkpoint inhibition (ICI). The detailed mechanisms by which TLS influence antitumor immune responses are only partially understood.<h4>Methods</h4>Clinically annotated tumor tissues of 27 patients with MCC were obtained prior to ICI therapy. Tumor samples were subjected to transcriptomic and multiplex immuno-visual profiling, T-cell receptor (TCR) clonotype mapping, as well as-in selected cases-spatial transcriptomics to comprehensively characterize the tumor immune microenvironment.<h4>Results</h4>Weighted gene co-expression network analysis (WGCNA) of transcriptomic data in "],"journal":["Journal for immunotherapy of cancer"],"pagination":["e012224"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12458699"],"repository":["biostudies-literature"],"pubmed_title":["Tertiary lymphoid structures in Merkel cell carcinoma facilitate naive and central memory T-cell infiltration linked to immunotherapy response."],"pmcid":["PMC12458699"],"pubmed_authors":["Pino MJ","Lei KC","Stoffels I","Gao J","Lui WO","Dalkoohi M","Leiter U","Ugurel S","Gambichler T","Mohr P","Spassova I","Cheung PF","Srinivas N","Livingstone E","Giglio G","Engblom C","Kitanovski S","Becker JC"],"additional_accession":[]},"is_claimable":false,"name":"Tertiary lymphoid structures in Merkel cell carcinoma facilitate naive and central memory T-cell infiltration linked to immunotherapy response.","description":"<h4>Background</h4>The presence of tertiary lymphoid structures (TLS) in solid tumors, including Merkel cell carcinoma (MCC), is associated with a better prognosis and a better response to immunotherapy with immune checkpoint inhibition (ICI). The detailed mechanisms by which TLS influence antitumor immune responses are only partially understood.<h4>Methods</h4>Clinically annotated tumor tissues of 27 patients with MCC were obtained prior to ICI therapy. Tumor samples were subjected to transcriptomic and multiplex immuno-visual profiling, T-cell receptor (TCR) clonotype mapping, as well as-in selected cases-spatial transcriptomics to comprehensively characterize the tumor immune microenvironment.<h4>Results</h4>Weighted gene co-expression network analysis (WGCNA) of transcriptomic data in ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T19:36:38.738Z","creation":"2026-04-30T03:12:24.845Z"},"accession":"S-EPMC12458699","cross_references":{"pubmed":["40992783"],"doi":["10.1136/jitc-2025-012224"]}}