biostudies-literatureUnknown12(2)D'Ascenzo F<h4>Introduction</h4>An evidence-based selection between fractional flow reserve (FFR) and optical coherence tomography (OCT) to drive percutaneous coronary intervention is still lacking.<h4>Methods</h4>Patients enrolled in the Fractional Flow Reserve vs. Optical Coherence Tomography to Guide Revascularization of Intermediate Coronary Stenoses (FORZA) trial and in the OCT-Features Of moRphology, coMposItion anD instABility of culprit and not culprit coronary pLaquE in ACS patient (OCT-FORMIDABLE) registry were included. Target vessel revascularisation (TVR) and major adverse cardiac events (MACE), a composite endpoint of cardiac death, myocardial infarction (MI) and TVR were considered as coprimary endpoints. Phenomapping with clustering was performed: incidence of outcomes according to FFOpen hearte003453https://www.ebi.ac.uk/biostudies/studies/S-EPMC12458727biostudies-literaturePhenomapping-derived selection of fractional flow reserve or optical coherence tomography to personalise percutaneous coronary intervention.PMC12458727Capodanno DSanavia TBruno FBurzotta FGiacobbe FBoccuzzi GDe Filippo OFariselli PLeone AMIannaccone MSouteyrand GSandrone SBorzillo ID'Ascenzo FAmabile NCaranzano IDe Ferrari GMUgo FAurigemma CRavetti ETrani CfalsePhenomapping-derived selection of fractional flow reserve or optical coherence tomography to personalise percutaneous coronary intervention.<h4>Introduction</h4>An evidence-based selection between fractional flow reserve (FFR) and optical coherence tomography (OCT) to drive percutaneous coronary intervention is still lacking.<h4>Methods</h4>Patients enrolled in the Fractional Flow Reserve vs. Optical Coherence Tomography to Guide Revascularization of Intermediate Coronary Stenoses (FORZA) trial and in the OCT-Features Of moRphology, coMposItion anD instABility of culprit and not culprit coronary pLaquE in ACS patient (OCT-FORMIDABLE) registry were included. Target vessel revascularisation (TVR) and major adverse cardiac events (MACE), a composite endpoint of cardiac death, myocardial infarction (MI) and TVR were considered as coprimary endpoints. Phenomapping with clustering was performed: incidence of outcomes according to FF2025-01-01T00:00:00Z2025 Sep2026-06-03T19:49:37.664Z2026-05-01T03:10:41.626ZS-EPMC124587274096767410.1136/openhrt-2025-003453