{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Bell RT"],"pubmed_abstract":["Bacteria and archaea possess an enormous variety of antivirus immune systems that often share homologous proteins and domains, some of which contribute to diverse defense strategies. YprA family helicases are central to widespread defense systems DISARM, Dpd, and Druantia. Here, through comprehensive phylogenetic and structural prediction analysis of the YprA family, we identify several major, previously unrecognized clades, with unique signatures of domain architecture and associations with other genes. Each YprA family clade defines a distinct class of defense systems, which we denote ARMADA (disARM-related Antiviral Defense Array), BRIGADE (Base hypermodification and Restriction Involving Genes encoding ARMADA-like and Dpd-like Effectors), or TALON (TOTE-like and ARMADA-Like Operon with"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.09.15.676423"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12458937"],"repository":["biostudies-literature"],"pubmed_title":["YprA family helicases provide the missing link between diverse prokaryotic immune systems."],"pmcid":["PMC12458937"],"pubmed_authors":["Beisel CL","Makarova KS","Wolf YI","Bell RT","Jackson SA","Koonin EV","Gaudin T","Sahakyan H","Wu Y","Garushyants SK","Nobrega FL"],"additional_accession":[]},"is_claimable":false,"name":"YprA family helicases provide the missing link between diverse prokaryotic immune systems.","description":"Bacteria and archaea possess an enormous variety of antivirus immune systems that often share homologous proteins and domains, some of which contribute to diverse defense strategies. YprA family helicases are central to widespread defense systems DISARM, Dpd, and Druantia. Here, through comprehensive phylogenetic and structural prediction analysis of the YprA family, we identify several major, previously unrecognized clades, with unique signatures of domain architecture and associations with other genes. Each YprA family clade defines a distinct class of defense systems, which we denote ARMADA (disARM-related Antiviral Defense Array), BRIGADE (Base hypermodification and Restriction Involving Genes encoding ARMADA-like and Dpd-like Effectors), or TALON (TOTE-like and ARMADA-Like Operon with","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-04T03:19:57.047Z","creation":"2026-05-04T03:14:03.391Z"},"accession":"S-EPMC12458937","cross_references":{"pubmed":["41000832"],"doi":["10.1101/2025.09.15.676423"]}}