{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rousselot E"],"funding":["Agence Nationale de la Recherche","European Research Council","European Research Council project","Région Pays de la Loire"],"pagination":["299"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12459048"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(1)"],"pubmed_abstract":["Background
Histones are among the most conserved proteins in eukaryotes. They not only ensure DNA compaction in the nucleus but also participate in epigenetic regulation of gene expression. These key epigenetic players are divided into replication-coupled histones, expressed during the S-phase, and replication-independent variants, expressed throughout the cell cycle. Compared with other core histones, H2A proteins exhibit a high level of variability but the characterization of algal H2A variants remains very limited.Results
In this study, we exploit genome and transcriptome data from 22 species to identify H2A variants in brown seaweeds. Combined analyses of phylogenetic data, synteny and protein motifs enable us to reveal the presence of new H2A variants as well as their "],"journal":["Genome biology"],"pubmed_title":["Identification of novel H2A histone variants across diverse clades of algae."],"pmcid":["PMC12459048"],"funding_grant_id":["France Génomique National infrastructure project Phaeoexplorer (ANR-10-INBS-09)","M-EPICC, Etoiles Montantes","638240","ConnecTalent EPIALG project"],"pubmed_authors":["Cock JM","Nehr Z","Tirichine L","Duc C","Aury JM","Denoeud F","Rousselot E"],"additional_accession":[]},"is_claimable":false,"name":"Identification of novel H2A histone variants across diverse clades of algae.","description":"Background
Histones are among the most conserved proteins in eukaryotes. They not only ensure DNA compaction in the nucleus but also participate in epigenetic regulation of gene expression. These key epigenetic players are divided into replication-coupled histones, expressed during the S-phase, and replication-independent variants, expressed throughout the cell cycle. Compared with other core histones, H2A proteins exhibit a high level of variability but the characterization of algal H2A variants remains very limited.Results
In this study, we exploit genome and transcriptome data from 22 species to identify H2A variants in brown seaweeds. Combined analyses of phylogenetic data, synteny and protein motifs enable us to reveal the presence of new H2A variants as well as their ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T20:07:26.181Z","creation":"2026-05-31T03:07:10.258Z"},"accession":"S-EPMC12459048","cross_references":{"pubmed":["40988048"],"doi":["10.1186/s13059-025-03656-w"]}}