{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(39)"],"submitter":["Pi Q"],"pubmed_abstract":["The plant cysteine protease metacaspases are structural homologs of animal caspases and play pivotal roles under biotic and abiotic stresses. However, whether metacaspases and purine-rich element (R-motif)-mediated defense messenger RNA translation are involved in plant antiviral immunity remains elusive. Here, we report that barley stripe mosaic virus (BSMV) infection activates metacaspase 4 (MC4) to cleave the RNA binding protein lupus autoantigen 1 (La1) behind residue arginine-448. The cleaved La1<sub>1-448</sub> version relocates to the cytoplasm and promotes the R-motif-mediated cap-independent defense mRNA translation. Moreover, MC4 overexpression restricts BSMV infection in tobacco (<i>Nicotiana benthamiana</i>), whereas knockout of <i>MC4</i> and knockdown of <i>La1</i> are more s"],"journal":["Science advances"],"pagination":["eadv0819"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12459463"],"repository":["biostudies-literature"],"pubmed_title":["The MC4-La1 cleavage module restricts plant virus infection by integrating R-motif-mediated defense mRNA translation."],"pmcid":["PMC12459463"],"pubmed_authors":["Jiang Z","Li D","Zhang Y","Yang M","Chen Y","Yue N","Wei J","Hu R","Song W","Wang J","Pi Q"],"additional_accession":[]},"is_claimable":false,"name":"The MC4-La1 cleavage module restricts plant virus infection by integrating R-motif-mediated defense mRNA translation.","description":"The plant cysteine protease metacaspases are structural homologs of animal caspases and play pivotal roles under biotic and abiotic stresses. However, whether metacaspases and purine-rich element (R-motif)-mediated defense messenger RNA translation are involved in plant antiviral immunity remains elusive. Here, we report that barley stripe mosaic virus (BSMV) infection activates metacaspase 4 (MC4) to cleave the RNA binding protein lupus autoantigen 1 (La1) behind residue arginine-448. The cleaved La1<sub>1-448</sub> version relocates to the cytoplasm and promotes the R-motif-mediated cap-independent defense mRNA translation. Moreover, MC4 overexpression restricts BSMV infection in tobacco (<i>Nicotiana benthamiana</i>), whereas knockout of <i>MC4</i> and knockdown of <i>La1</i> are more s","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T19:49:56.34Z","creation":"2026-05-01T03:10:44.862Z"},"accession":"S-EPMC12459463","cross_references":{"pubmed":["40991707"],"doi":["10.1126/sciadv.adv0819"]}}