biostudies-literatureUnknown15(42)Zhang YA Cu-bis(sulfonamide)-diamine complex catalytic system was exploited in asymmetric Henry reactions to construct versatile chiral nitroalcohols with high enantioselectivity from carbamate-acetaldehydes and nitromethane. This elegant approach was further implemented to complete the asymmetric total syntheses of a series of oxazolidone skeleton drugs, such as linezolid (antibiotic) and rivaroxaban (anti-coagulant), in a concise and efficient way.RSC advances35292-35295https://www.ebi.ac.uk/biostudies/studies/S-EPMC12459656biostudies-literatureCu-diamine ligand-controlled asymmetric Henry reactions and their application in concise total syntheses of linezolid and rivaroxaban.PMC12459656Zhang YXiao WfalseCu-diamine ligand-controlled asymmetric Henry reactions and their application in concise total syntheses of linezolid and rivaroxaban.A Cu-bis(sulfonamide)-diamine complex catalytic system was exploited in asymmetric Henry reactions to construct versatile chiral nitroalcohols with high enantioselectivity from carbamate-acetaldehydes and nitromethane. This elegant approach was further implemented to complete the asymmetric total syntheses of a series of oxazolidone skeleton drugs, such as linezolid (antibiotic) and rivaroxaban (anti-coagulant), in a concise and efficient way.2025-01-01T00:00:00Z2025 Sep2026-06-03T20:18:36.016Z2026-05-01T03:10:35.952ZS-EPMC124596564100061010.1039/d5ra05795g