{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["645(8082)"],"submitter":["Zhao Y"],"pubmed_abstract":["T cells respond to cytokines through receptor dimers that have been selected over the course of evolution to activate canonical JAK-STAT signalling and gene expression programs<sup>1</sup>. However, the potential combinatorial diversity of JAK-STAT receptor pairings can be expanded by exploring the untapped biology of alternative non-natural pairings. Here we exploited the common γ chain (γ<sub>c</sub>) receptor as a shared signalling hub on T cells and enforced the expression of both natural and non-natural heterodimeric JAK-STAT receptor pairings using an orthogonal cytokine receptor platform<sup>2-4</sup> to expand the γ<sub>c</sub> signalling code. We tested receptors from γ<sub>c</sub> cytokines as well as interferon, IL-10 and homodimeric receptor families that do not normally pair w"],"journal":["Nature"],"pagination":["1039-1050"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12460165"],"repository":["biostudies-literature"],"pubmed_title":["Expanding the cytokine receptor alphabet reprograms T cells into diverse states."],"pmcid":["PMC12460165"],"pubmed_authors":["Ogishi M","Waghray D","Garcia KC","Jiang H","Pal A","Kalbasi A","Zhao Y","Rysavy LW","Sun Q","Rodriguez GE","Su LL","Chen X","Limsuwannarot S","Tao P"],"additional_accession":[]},"is_claimable":false,"name":"Expanding the cytokine receptor alphabet reprograms T cells into diverse states.","description":"T cells respond to cytokines through receptor dimers that have been selected over the course of evolution to activate canonical JAK-STAT signalling and gene expression programs<sup>1</sup>. However, the potential combinatorial diversity of JAK-STAT receptor pairings can be expanded by exploring the untapped biology of alternative non-natural pairings. Here we exploited the common γ chain (γ<sub>c</sub>) receptor as a shared signalling hub on T cells and enforced the expression of both natural and non-natural heterodimeric JAK-STAT receptor pairings using an orthogonal cytokine receptor platform<sup>2-4</sup> to expand the γ<sub>c</sub> signalling code. We tested receptors from γ<sub>c</sub> cytokines as well as interferon, IL-10 and homodimeric receptor families that do not normally pair w","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T19:37:50.943Z","creation":"2026-04-30T03:12:27.299Z"},"accession":"S-EPMC12460165","cross_references":{"pubmed":["40804519"],"doi":["10.1038/s41586-025-09393-1"]}}