biostudies-literatureGeng YNational Natural Science Foundation of China1789-1800https://www.ebi.ac.uk/biostudies/studies/S-EPMC12460372biostudies-literatureUnknown53(5)<h4>Background</h4>The effectiveness of infection prevention and control measures combating multidrug-resistant organisms (MDROs) in healthcare settings remains controversial.<h4>Methods</h4>PubMed, Embase, MEDLINE, Cochrane Library, and CINAHL were searched from inception to June 1, 2024. The interventions encompassed standard precautions (SP), contact precautions (CP), hand hygiene (HH), environmental cleaning (ENV), antimicrobial stewardship programs (ASP), decolonization (DCL), and chlorhexidine baths (CHG). The primary outcome were the acquisition, infection, and colonization of MDROs. Secondary outcomes were all-cause mortality and MDROs-associated bacteraemia. Effect indicators were expressed as rate ratios (RRs) with 95% confidence intervals (CIs).<h4>Results</h4>The study includedInfectionInfection prevention and control measures for multidrug-resistant organisms: a systematic review and network meta-analysis.PMC1246037282360657Liu ZDang JPan TPan DChen MMa XGeng YChen CLiang PZhao YZhang PfalseInfection prevention and control measures for multidrug-resistant organisms: a systematic review and network meta-analysis.<h4>Background</h4>The effectiveness of infection prevention and control measures combating multidrug-resistant organisms (MDROs) in healthcare settings remains controversial.<h4>Methods</h4>PubMed, Embase, MEDLINE, Cochrane Library, and CINAHL were searched from inception to June 1, 2024. The interventions encompassed standard precautions (SP), contact precautions (CP), hand hygiene (HH), environmental cleaning (ENV), antimicrobial stewardship programs (ASP), decolonization (DCL), and chlorhexidine baths (CHG). The primary outcome were the acquisition, infection, and colonization of MDROs. Secondary outcomes were all-cause mortality and MDROs-associated bacteraemia. Effect indicators were expressed as rate ratios (RRs) with 95% confidence intervals (CIs).<h4>Results</h4>The study included2025-01-01T00:00:00Z2025 Oct2026-07-15T21:56:22.308Z2026-07-09T10:18:27.825ZS-EPMC124603724009536110.1007/s15010-025-02498-9