{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lopez-Cervantes M"],"funding":["DGAPA, PAPPIT","Consejo Nacional de Humanidades, Ciencias y Tecnologías","Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México"],"pagination":["274"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12460505"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(7)"],"pubmed_abstract":["Portacaval anastomosis (PCA) is a model for hypometabolic liver dysfunction. Spongiform neurodegeneration has been detected in the cerebellum of PCA rats 13 weeks after surgery. This report characterizes the damage associated with spongiform degeneration by studying mitochondrial, ultrastructural, and oxidative changes in the molecular, Purkinje, and granular layers of the cerebellar cortex. Morphometry by electron microscopy determined an increase in mitochondrial presence in PCA rats. In parallel, mitochondria displayed smaller size, diminished interconnectivity, and decreased elongation. Fluorescent probes revealed that PCA cerebellar mitochondria showed a reduction in membrane potential (ΔΨ) alongside a rise in superoxide levels. In contrast, the calcium content exhibited variability a"],"journal":["Metabolic brain disease"],"pubmed_title":["Portacaval anastomosis promotes fragmentation of mitochondrial network in the cerebellum of male rats."],"pmcid":["PMC12460505"],"funding_grant_id":["994581","IN207224","IN207224 to MD-M"],"pubmed_authors":["Lopez-Cervantes M","Quintanar-Stephano A","Diaz-Munoz M","Vazquez-Martinez O","Hernandez-Pando R","Martinez-Cabrera G","Aguilar-Roblero R","Larriva-Sahd J"],"additional_accession":[]},"is_claimable":false,"name":"Portacaval anastomosis promotes fragmentation of mitochondrial network in the cerebellum of male rats.","description":"Portacaval anastomosis (PCA) is a model for hypometabolic liver dysfunction. Spongiform neurodegeneration has been detected in the cerebellum of PCA rats 13 weeks after surgery. This report characterizes the damage associated with spongiform degeneration by studying mitochondrial, ultrastructural, and oxidative changes in the molecular, Purkinje, and granular layers of the cerebellar cortex. Morphometry by electron microscopy determined an increase in mitochondrial presence in PCA rats. In parallel, mitochondria displayed smaller size, diminished interconnectivity, and decreased elongation. Fluorescent probes revealed that PCA cerebellar mitochondria showed a reduction in membrane potential (ΔΨ) alongside a rise in superoxide levels. In contrast, the calcium content exhibited variability a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-05T05:11:13.47Z","creation":"2026-05-13T14:29:18.806Z"},"accession":"S-EPMC12460505","cross_references":{"pubmed":["40991132"],"doi":["10.1007/s11011-025-01705-8"]}}