{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ovalle A"],"funding":["Agencia Nacional de Investigación y Desarrollo"],"pagination":["185"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12460604"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["The gut-brain axis enables communication between the central nervous system and the gut, with certain microbial metabolites influencing neurodegeneration. Using genome-scale metabolic modeling, we designed and tested a synthetic microbial consortium with predicted capacity to produce GABA and other neurometabolites in a Drosophila melanogaster model of neurodegeneration of Parkinson's Disease (PD). The consortium (Levilactobacillus brevis, Lacticaseibacillus paracasei, Bacteroides thetaiotaomicron) produced GABA in bioreactors. Female PD flies receiving the consortium exhibited protection from locomotor impairment at 10 and 25 days upon consortium administration. Head metabolomics revealed partial restoration of PD-associated alterations in energy balance, amino acid and neurotransmitter m"],"journal":["NPJ biofilms and microbiomes"],"pubmed_title":["A rationally designed microbial consortium modulates neurodegeneration in a Drosophila melanogaster model of Parkinson's disease."],"pmcid":["PMC12460604"],"funding_grant_id":["21190847","1230764"],"pubmed_authors":["Paricio N","Ovalle A","Lopez E","Garrido D","Sierralta J"],"additional_accession":[]},"is_claimable":false,"name":"A rationally designed microbial consortium modulates neurodegeneration in a Drosophila melanogaster model of Parkinson's disease.","description":"The gut-brain axis enables communication between the central nervous system and the gut, with certain microbial metabolites influencing neurodegeneration. Using genome-scale metabolic modeling, we designed and tested a synthetic microbial consortium with predicted capacity to produce GABA and other neurometabolites in a Drosophila melanogaster model of neurodegeneration of Parkinson's Disease (PD). The consortium (Levilactobacillus brevis, Lacticaseibacillus paracasei, Bacteroides thetaiotaomicron) produced GABA in bioreactors. Female PD flies receiving the consortium exhibited protection from locomotor impairment at 10 and 25 days upon consortium administration. Head metabolomics revealed partial restoration of PD-associated alterations in energy balance, amino acid and neurotransmitter m","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T19:38:23.426Z","creation":"2026-04-30T03:12:29.372Z"},"accession":"S-EPMC12460604","cross_references":{"pubmed":["40993130"],"doi":["10.1038/s41522-025-00797-5"]}}