{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sarnowski C"],"funding":["NIA NIH HHS"],"pagination":["1352"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12460837"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["To better characterize the potential biological mechanisms underlying insulin resistance (IR) and dementia, we derive cross-population and population specific polygenic scores [PSs] for fasting insulin and IR-related partitioned PSs [pPSs]. We conduct a cross-sectional study of the associations of these genetic scores with neurological outcomes in >17k participants (36% men, mean age 55 yrs) from the Trans-Omics for Precision Medicine (TOPMed) program (50% Non-Hispanic White, 23% Black/African American, 21% Hispanic/Latino American, and 4% Asian American). We report significant negative associations (P < 0.002) of the cross-population (P = 1.3 × 10<sup>-5</sup>) and European (P<sub>EA</sub> = 3.0 × 10<sup>-8</sup>) fasting insulin PSs with total cranial volume, and of a metabolic syndrome "],"journal":["Communications biology"],"pubmed_title":["Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program."],"pmcid":["PMC12460837"],"funding_grant_id":["R00 AG066849"],"pubmed_authors":["Psaty BM","Manning AK","Dupuis J","Florez JC","Kardia SLR","Rotter JI","Bressler J","Gibbs RA","Boerwinkle E","Rich SS","Morrison AC","Mandla R","Mosley TH","Curran JE","Gabriel S","Hughes TM","Gupta N","Hayden KM","T2DGGI consortium","TOPMed Diabetes working group","MAGIC consortium","Raffield LM","Wassertheil-Smoller S","Wood AC","Huerta-Chagoya A","Nasrallah IM","DiCorpo D","Ammous F","DeCarli CS","Fardo DW","Fornage M","Sarnowski C","Udler MS","Jian X","Yanek LR","Viaud-Martinez KA","Nyquist P","Meigs JB","Beiser A","Blangero J","Gonzalez KA","Suzuki K","Taylor HJ","Satizabal CL","Qi Q","Kooperberg CL","Selvin E","Snively BM","Sofer T","Smith AV","Arnett DK","Glahn DC","Smith JA","Morris AP","Doddapaneni H","Southam L","Yin X","Reiner AP","Austin TR","Hatzikotoulas K","Hidalgo B","Heckbert SR","Smith K","Longstreth WT","Seshadri S","Rayner NW","Bis JC","Mathias RA","and the TOPMed Neurocognitive working group","Sevilla-Gonzalez MDR","Zhang Y","Shade LMP","Launer LJ","Gonzalez HM"],"additional_accession":[]},"is_claimable":false,"name":"Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program.","description":"To better characterize the potential biological mechanisms underlying insulin resistance (IR) and dementia, we derive cross-population and population specific polygenic scores [PSs] for fasting insulin and IR-related partitioned PSs [pPSs]. We conduct a cross-sectional study of the associations of these genetic scores with neurological outcomes in >17k participants (36% men, mean age 55 yrs) from the Trans-Omics for Precision Medicine (TOPMed) program (50% Non-Hispanic White, 23% Black/African American, 21% Hispanic/Latino American, and 4% Asian American). We report significant negative associations (P < 0.002) of the cross-population (P = 1.3 × 10<sup>-5</sup>) and European (P<sub>EA</sub> = 3.0 × 10<sup>-8</sup>) fasting insulin PSs with total cranial volume, and of a metabolic syndrome ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T20:09:20.429Z","creation":"2026-05-31T03:07:27.135Z"},"accession":"S-EPMC12460837","cross_references":{"pubmed":["40993182"],"doi":["10.1038/s42003-025-08674-9"]}}