{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McDowell RJ"],"funding":["European Research Council"],"pagination":["msaf158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12461567"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(9)"],"pubmed_abstract":["Melanopsin is a light-sensitive G-protein coupled receptor responsible for essential visual and non-visual light-mediated behaviors in mammals. Human melanopsin shows maximal sensitivity (λmax) in the blue region of the spectrum (∼480 nm), and available evidence suggests that this spectral sensitivity may be retained across mammals. However, melanopsin spectral sensitivity has been defined for only a small number of species, and the molecular mechanisms determining this property remain poorly understood. Here, we use heterologous action spectroscopy to determine the spectral sensitivity of melanopsins from 8 mammalian species, selected to cover diversity in retinal physiology, lighting niche, and evolutionary distance, and of engineered mutants of mouse melanopsin designed to explore mecha"],"journal":["Molecular biology and evolution"],"pubmed_title":["Spectral Tuning in Mammalian Melanopsins."],"pmcid":["PMC12461567"],"funding_grant_id":["951644","951644-SOL"],"pubmed_authors":["Lucas RJ","Notash S","McDowell RJ","Gatt MJ"],"additional_accession":[]},"is_claimable":false,"name":"Spectral Tuning in Mammalian Melanopsins.","description":"Melanopsin is a light-sensitive G-protein coupled receptor responsible for essential visual and non-visual light-mediated behaviors in mammals. Human melanopsin shows maximal sensitivity (λmax) in the blue region of the spectrum (∼480 nm), and available evidence suggests that this spectral sensitivity may be retained across mammals. However, melanopsin spectral sensitivity has been defined for only a small number of species, and the molecular mechanisms determining this property remain poorly understood. Here, we use heterologous action spectroscopy to determine the spectral sensitivity of melanopsins from 8 mammalian species, selected to cover diversity in retinal physiology, lighting niche, and evolutionary distance, and of engineered mutants of mouse melanopsin designed to explore mecha","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-01T03:22:29.399Z","creation":"2026-05-01T03:11:08.768Z"},"accession":"S-EPMC12461567","cross_references":{"pubmed":["40995967"],"doi":["10.1093/molbev/msaf158"]}}