{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(9)"],"submitter":["Wu J"],"funding":["This study was supported by Weilong Zhong (Nos. 2021A1515111009 and 82203900), Bo Yu (Nos. SZSM202311029 and SZXK040), and Xia Dou (Nos. JCYJ20210324105411030 and KYQD2021016)."],"pubmed_abstract":["<h4>Background</h4>The available evidence increasingly indicates that SERPINB3/4 plays a pivotal role in the progression of inflammatory diseases and may serve as a valuable biomarker for atopic dermatitis and psoriasis. However, the expression of SERPINB3/4 in the serum of patients with moderate-to-severe prurigo nodularis (PN) remains poorly understood.<h4>Objective</h4>To find a promising biomarker for monitoring the severity and activity of moderate-to-severe PN patients.<h4>Methods</h4>A total of 41 patients with moderate-to-severe PN and 20 healthy subjects were included in the study. Enzyme-linked immunosorbent assay (ELISA) was performed to determine serum SERPINB3/4 expression. Cutaneous SERPINB3/4 expression was evaluated by immunohistochemistry (IHC). Serum SERPINB3/4 levels wer"],"journal":["Immunity, inflammation and disease"],"pagination":["e70263"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12461664"],"repository":["biostudies-literature"],"pubmed_title":["Serum SERPINB3/4 in Moderate-to-Severe Prurigo Nodularis: A Potential Biomarker for Disease Severity and Eosinophil-Related Parameters."],"pmcid":["PMC12461664"],"pubmed_authors":["Dou X","Wu J","Liao Y","Zhang K","Yu B","Shao Y","Wu C","Ge J","Zhong W","Yang C"],"additional_accession":[]},"is_claimable":false,"name":"Serum SERPINB3/4 in Moderate-to-Severe Prurigo Nodularis: A Potential Biomarker for Disease Severity and Eosinophil-Related Parameters.","description":"<h4>Background</h4>The available evidence increasingly indicates that SERPINB3/4 plays a pivotal role in the progression of inflammatory diseases and may serve as a valuable biomarker for atopic dermatitis and psoriasis. However, the expression of SERPINB3/4 in the serum of patients with moderate-to-severe prurigo nodularis (PN) remains poorly understood.<h4>Objective</h4>To find a promising biomarker for monitoring the severity and activity of moderate-to-severe PN patients.<h4>Methods</h4>A total of 41 patients with moderate-to-severe PN and 20 healthy subjects were included in the study. Enzyme-linked immunosorbent assay (ELISA) was performed to determine serum SERPINB3/4 expression. Cutaneous SERPINB3/4 expression was evaluated by immunohistochemistry (IHC). Serum SERPINB3/4 levels wer","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-01T03:07:32.286Z","creation":"2026-06-01T03:06:01.338Z"},"accession":"S-EPMC12461664","cross_references":{"pubmed":["40995892"],"doi":["10.1002/iid3.70263"]}}