{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(9)"],"submitter":["Hughes Y"],"pubmed_abstract":["<h4>Background</h4>Earlier syphilis detection is needed to reduce infectiousness and transmission and to improve control. Polymerase chain reaction (PCR) for <i>Treponema pallidum</i> is highly sensitive for detecting primary syphilis but is not often widely available or used. The aim of this systematic review and meta-analysis was to investigate the proportion of PCR-positive, seronegative primary syphilis infections when serology was performed at clinical presentation.<h4>Methods</h4>We undertook a systematic review and meta-analysis to identify studies of patients presenting with primary syphilis where <i>T pallidum</i> PCR was performed on the primary syphilis lesion and serology for syphilis was performed on the same occasion. The review was conducted according to the Cochrane protoco"],"journal":["Open forum infectious diseases"],"pagination":["ofaf471"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12461845"],"repository":["biostudies-literature"],"pubmed_title":["The Proportion of &lt;i&gt;Treponema pallidum&lt;/i&gt; Polymerase Chain Reaction-Positive Primary Syphilis Infections That Are Seronegative for Syphilis: A Systematic Review and Meta-analysis."],"pmcid":["PMC12461845"],"pubmed_authors":["Azzato F","Ong JJ","Chow EPF","Chen MY","Williams E","Bilardi J","Pasricha S","Fairley CK","Towns JM","Hocking JS","Hughes Y","Williamson DA"],"additional_accession":[]},"is_claimable":false,"name":"The Proportion of &lt;i&gt;Treponema pallidum&lt;/i&gt; Polymerase Chain Reaction-Positive Primary Syphilis Infections That Are Seronegative for Syphilis: A Systematic Review and Meta-analysis.","description":"<h4>Background</h4>Earlier syphilis detection is needed to reduce infectiousness and transmission and to improve control. Polymerase chain reaction (PCR) for <i>Treponema pallidum</i> is highly sensitive for detecting primary syphilis but is not often widely available or used. The aim of this systematic review and meta-analysis was to investigate the proportion of PCR-positive, seronegative primary syphilis infections when serology was performed at clinical presentation.<h4>Methods</h4>We undertook a systematic review and meta-analysis to identify studies of patients presenting with primary syphilis where <i>T pallidum</i> PCR was performed on the primary syphilis lesion and serology for syphilis was performed on the same occasion. The review was conducted according to the Cochrane protoco","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-02T03:16:06.449Z","creation":"2026-05-02T03:08:09.709Z"},"accession":"S-EPMC12461845","cross_references":{"pubmed":["41018698"],"doi":["10.1093/ofid/ofaf471"]}}