{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Coley K"],"funding":["Medical Research Council","NIHR Leicester Biomedical Research Centre","Orion Corporation","National Institute for Health Research (NIHR)","National Institute for Health and Care Research","Wellcome Trust","NIHR Barts Biomedical Research Centre, Queen Mary University of London"],"pagination":["2402341"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12461901"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["66(3)"],"pubmed_abstract":["<h4>Background</h4>Chronic dry cough is a symptom of common lung conditions, can occur as a side-effect of angiotensin-converting enzyme inhibitors (ACEis), or may be unexplained. Despite the substantial health burden presented by chronic dry cough, its biological mechanisms remain unclear. We hypothesised shared genetic architecture between chronic dry cough and ACEi-induced cough and aimed to identify causal genes underlying both phenotypes.<h4>Methods</h4>We performed multi-ancestry genome-wide association studies (GWAS) of chronic dry cough and ACEi-induced cough, and a multi-trait GWAS of both phenotypes, utilising data from five cohort studies. Chronic dry cough was defined by questionnaire responses, and ACEi-induced cough by treatment switches or clinical diagnosis in electronic he"],"journal":["The European respiratory journal"],"pubmed_title":["Genomics of chronic dry cough unravels neurological pathways."],"pmcid":["PMC12461901"],"funding_grant_id":["WT225221/Z/22/Z","WT202849/Z/16/Z","225221","NIHR201371","MR/S003762/1"],"pubmed_authors":["McGarvey L","Bundgaard H","Tobin MD","Genes and Health Research Team","Hennah W","Shepherd DJ","Magavern EF","Erikstrup C","Packer R","Wain LV","Batini C","Marttila M","Ghouse J","Ostrowski SR","Coley K","Hollox EJ","van Heel DA","Pedersen OBV","Shrine N","Kanoni S","Smith JA","John C","Izquierdo AG","Free RC"],"additional_accession":[]},"is_claimable":false,"name":"Genomics of chronic dry cough unravels neurological pathways.","description":"<h4>Background</h4>Chronic dry cough is a symptom of common lung conditions, can occur as a side-effect of angiotensin-converting enzyme inhibitors (ACEis), or may be unexplained. Despite the substantial health burden presented by chronic dry cough, its biological mechanisms remain unclear. We hypothesised shared genetic architecture between chronic dry cough and ACEi-induced cough and aimed to identify causal genes underlying both phenotypes.<h4>Methods</h4>We performed multi-ancestry genome-wide association studies (GWAS) of chronic dry cough and ACEi-induced cough, and a multi-trait GWAS of both phenotypes, utilising data from five cohort studies. Chronic dry cough was defined by questionnaire responses, and ACEi-induced cough by treatment switches or clinical diagnosis in electronic he","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-07-15T11:57:00.921Z","creation":"2026-07-04T03:11:44.993Z"},"accession":"S-EPMC12461901","cross_references":{"pubmed":["40675770"],"doi":["10.1183/13993003.02341-2024"]}}