{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li X"],"funding":["National Key Research and Development Program of China"],"pagination":["303"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12461997"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(1)"],"pubmed_abstract":["<h4>Background</h4>Histone modifications are critical for transcriptional regulation. A notable genetic innovation in land plants is the emergence of histone lysine methyltransferases ATXR5/6, which specifically catalyze the repressive histone H3 lysine 27 monomethylation (H3K27me1). Current knowledge of ATXR5/6 function is largely based on Arabidopsis studies using a weak atxr5;atxr6 hypomorphic mutant, in which ATXR6 is still partially expressed and defects are primarily observed in heterochromatin. However, the significance for land plants to evolve these enzymes remains unclear.<h4>Results</h4>In this study, we generate strong atxr5;atxr6 mutants with further reduced ATXR6 expression in Arabidopsis to explore the broader roles of ATXR5/6. Our results show that ATXR5/6 are essential for"],"journal":["Genome biology"],"pubmed_title":["Land plant-specific H3K27 methyltransferases ATXR5 and ATXR6 control plant development and stress responses."],"pmcid":["PMC12461997"],"funding_grant_id":["2023YFD1200704"],"pubmed_authors":["Li X","Li H","Pan J","Zhang H","Liu Q","Jiang D"],"additional_accession":[]},"is_claimable":false,"name":"Land plant-specific H3K27 methyltransferases ATXR5 and ATXR6 control plant development and stress responses.","description":"<h4>Background</h4>Histone modifications are critical for transcriptional regulation. A notable genetic innovation in land plants is the emergence of histone lysine methyltransferases ATXR5/6, which specifically catalyze the repressive histone H3 lysine 27 monomethylation (H3K27me1). Current knowledge of ATXR5/6 function is largely based on Arabidopsis studies using a weak atxr5;atxr6 hypomorphic mutant, in which ATXR6 is still partially expressed and defects are primarily observed in heterochromatin. However, the significance for land plants to evolve these enzymes remains unclear.<h4>Results</h4>In this study, we generate strong atxr5;atxr6 mutants with further reduced ATXR6 expression in Arabidopsis to explore the broader roles of ATXR5/6. Our results show that ATXR5/6 are essential for","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T20:32:44.811Z","creation":"2026-05-01T03:11:02.902Z"},"accession":"S-EPMC12461997","cross_references":{"pubmed":["40999518"],"doi":["10.1186/s13059-025-03801-5"]}}