{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(8)"],"submitter":["Szerlip M"],"pubmed_abstract":["<h4>Background</h4>Female patients with degenerative mitral regurgitation (DMR) can have worse mitral valve repair outcomes. We aim to study sex-specific differences in contemporary mitral transcatheter edge-to-edge repair (M-TEER).<h4>Methods</h4>One-year outcomes in prohibitive surgical risk patients with 3+/4+ DMR from the randomized CLASP IID trial were analyzed by sex.<h4>Results</h4>The analysis population comprised 34.7% female patients (n = 102) and 65.3% male patients (n = 192). Female patients had significantly lower body mass index, fewer comorbidities, and smaller left ventricular indexed volumes and mitral valve area at baseline. At 1 year, there were no significant differences between female and male patients in survival (92.1% vs 90.9%, <i>P</i> = .754), freedom from heart f"],"journal":["Journal of the Society for Cardiovascular Angiography & Interventions"],"pagination":["103713"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12462154"],"repository":["biostudies-literature"],"pubmed_title":["Sex-Specific Outcomes of Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation: Results From the CLASP IID Trial."],"pmcid":["PMC12462154"],"pubmed_authors":["Gillam LD","Ruf TF","Koulogiannis K","Stephan von Bardeleben R","Zahr F","Szerlip M","Rassi AN","Hausleiter J","Chadderdon S","CLASP IID Pivotal Trial Investigators","Lim DS","Makkar RR","Kipperman RM","Goldman S","Marcoff L","Smith RL"],"additional_accession":[]},"is_claimable":false,"name":"Sex-Specific Outcomes of Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation: Results From the CLASP IID Trial.","description":"<h4>Background</h4>Female patients with degenerative mitral regurgitation (DMR) can have worse mitral valve repair outcomes. We aim to study sex-specific differences in contemporary mitral transcatheter edge-to-edge repair (M-TEER).<h4>Methods</h4>One-year outcomes in prohibitive surgical risk patients with 3+/4+ DMR from the randomized CLASP IID trial were analyzed by sex.<h4>Results</h4>The analysis population comprised 34.7% female patients (n = 102) and 65.3% male patients (n = 192). Female patients had significantly lower body mass index, fewer comorbidities, and smaller left ventricular indexed volumes and mitral valve area at baseline. At 1 year, there were no significant differences between female and male patients in survival (92.1% vs 90.9%, <i>P</i> = .754), freedom from heart f","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-03T22:56:54.211Z","creation":"2026-05-02T03:12:01.414Z"},"accession":"S-EPMC12462154","cross_references":{"pubmed":["41019910"],"doi":["10.1016/j.jscai.2025.103713"]}}