biostudies-literatureUnknown4(8)Szerlip M<h4>Background</h4>Female patients with degenerative mitral regurgitation (DMR) can have worse mitral valve repair outcomes. We aim to study sex-specific differences in contemporary mitral transcatheter edge-to-edge repair (M-TEER).<h4>Methods</h4>One-year outcomes in prohibitive surgical risk patients with 3+/4+ DMR from the randomized CLASP IID trial were analyzed by sex.<h4>Results</h4>The analysis population comprised 34.7% female patients (n = 102) and 65.3% male patients (n = 192). Female patients had significantly lower body mass index, fewer comorbidities, and smaller left ventricular indexed volumes and mitral valve area at baseline. At 1 year, there were no significant differences between female and male patients in survival (92.1% vs 90.9%, <i>P</i> = .754), freedom from heart fJournal of the Society for Cardiovascular Angiography & Interventions103713https://www.ebi.ac.uk/biostudies/studies/S-EPMC12462154biostudies-literatureSex-Specific Outcomes of Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation: Results From the CLASP IID Trial.PMC12462154Gillam LDRuf TFKoulogiannis KStephan von Bardeleben RZahr FSzerlip MRassi ANHausleiter JChadderdon SCLASP IID Pivotal Trial InvestigatorsLim DSMakkar RRKipperman RMGoldman SMarcoff LSmith RLfalseSex-Specific Outcomes of Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation: Results From the CLASP IID Trial.<h4>Background</h4>Female patients with degenerative mitral regurgitation (DMR) can have worse mitral valve repair outcomes. We aim to study sex-specific differences in contemporary mitral transcatheter edge-to-edge repair (M-TEER).<h4>Methods</h4>One-year outcomes in prohibitive surgical risk patients with 3+/4+ DMR from the randomized CLASP IID trial were analyzed by sex.<h4>Results</h4>The analysis population comprised 34.7% female patients (n = 102) and 65.3% male patients (n = 192). Female patients had significantly lower body mass index, fewer comorbidities, and smaller left ventricular indexed volumes and mitral valve area at baseline. At 1 year, there were no significant differences between female and male patients in survival (92.1% vs 90.9%, <i>P</i> = .754), freedom from heart f2025-01-01T00:00:00Z2025 Aug2026-06-03T22:56:54.211Z2026-05-02T03:12:01.414ZS-EPMC124621544101991010.1016/j.jscai.2025.103713