biostudies-literatureLiu WNatural Science Foundation of Zhejiang ProvinceWenzhou basic scientific research project1014https://www.ebi.ac.uk/biostudies/studies/S-EPMC12462272biostudies-literatureUnknown23(1)<h4>Purpose</h4>To measure alterations in quadrant asymmetry (QA) of retinal radial peripapillary capillary (RPC) density and to determine the association between subfield alterations and thyroid-associated ophthalmopathy (TAO).<h4>Methods</h4>Optical coherence tomography angiography images of 51 control eyes and 80 TAO eyes were analyzed to quantify RPC density. QA was defined as the difference between the maximum and minimum RPC densities among four subfields. Comparisons of RPC QA between groups and the associations of QA with the occurrence of TAO were analyzed. Linear regression was conducted to determine the association of subfield alterations with visual field mean deviation (MD).<h4>Results</h4>QA of RPC density in TAO eyes was higher than in control eyes (9.58 ± 2.40 vs. 6.70 ± 2.Journal of translational medicineQuadrant asymmetry alteration of retinal degeneration in thyroid-associated ophthalmopathy.PMC12462272LQ21H120007Y2023815Zhu JRao WHu XWu WTu YLiu WYe JfalseQuadrant asymmetry alteration of retinal degeneration in thyroid-associated ophthalmopathy.<h4>Purpose</h4>To measure alterations in quadrant asymmetry (QA) of retinal radial peripapillary capillary (RPC) density and to determine the association between subfield alterations and thyroid-associated ophthalmopathy (TAO).<h4>Methods</h4>Optical coherence tomography angiography images of 51 control eyes and 80 TAO eyes were analyzed to quantify RPC density. QA was defined as the difference between the maximum and minimum RPC densities among four subfields. Comparisons of RPC QA between groups and the associations of QA with the occurrence of TAO were analyzed. Linear regression was conducted to determine the association of subfield alterations with visual field mean deviation (MD).<h4>Results</h4>QA of RPC density in TAO eyes was higher than in control eyes (9.58 ± 2.40 vs. 6.70 ± 2.2025-01-01T00:00:00Z2025 Sep2026-05-01T03:22:14.257Z2026-05-01T03:11:06.419ZS-EPMC124622724099365310.1186/s12967-025-07043-8