{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Serrat J"],"funding":["Junta de Castilla y León","Ministerio de Ciencia e Innovación","MICIU/AEI/10.13039/501100011033 and FEDER, EU","MICIU/AEI/10.13039/501100011033 and NextGenerationEU/PRTR"],"pagination":["387"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12462368"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["Background
Fasciola hepatica is the most common etiologic agent of fasciolosis, a parasitic disease that affects millions of ruminants worldwide and a zoonotic human infection of public health concern. Upon ingestion of infective metacercariae, F. hepatica newly excysted juveniles (FhNEJ) emerge in the duodenum and cross the intestinal wall to initiate a migration route that culminates with their establishment within the hepatic bile ducts. The ability of FhNEJ to exploit the broad-spectrum activities of host plasmin, the central protease of the fibrinolytic system, has been proposed as a strategy employed by these parasites to migrate across the intestinal wall while minimising energy expenditure.Methods
Mouse intestinal epithelial cells (mPSIEC) were stimulated with FhNEJ"],"journal":["Parasites & vectors"],"pubmed_title":["Early host-parasite interaction models reveal a key role for fibrinolysis in Fasciola hepatica intestinal migration."],"pmcid":["PMC12462368"],"funding_grant_id":["Predoctoral contract","CNS2022-135561","PID2023-152150OB-C21","FPU predoctoral contract"],"pubmed_authors":["Ruiz-Campillo MT","Siles-Lucas M","Lopez-Garcia M","Torres-Valle M","Molina-Hernandez V","Serrat J","Gonzalez-Miguel J"],"additional_accession":[]},"is_claimable":false,"name":"Early host-parasite interaction models reveal a key role for fibrinolysis in Fasciola hepatica intestinal migration.","description":"Background
Fasciola hepatica is the most common etiologic agent of fasciolosis, a parasitic disease that affects millions of ruminants worldwide and a zoonotic human infection of public health concern. Upon ingestion of infective metacercariae, F. hepatica newly excysted juveniles (FhNEJ) emerge in the duodenum and cross the intestinal wall to initiate a migration route that culminates with their establishment within the hepatic bile ducts. The ability of FhNEJ to exploit the broad-spectrum activities of host plasmin, the central protease of the fibrinolytic system, has been proposed as a strategy employed by these parasites to migrate across the intestinal wall while minimising energy expenditure.Methods
Mouse intestinal epithelial cells (mPSIEC) were stimulated with FhNEJ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T20:28:00.162Z","creation":"2026-06-01T03:06:20.754Z"},"accession":"S-EPMC12462368","cross_references":{"pubmed":["40993705"],"doi":["10.1186/s13071-025-06992-9"]}}